Final Exam: NR546/ NR 546 (NEW Update 2024/ 2025) Psychopharmacology for the
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... [Show More] Correct- Chamberlain
QUESTION
MAOI use
Answer:
LAST choice for depression because of many potential, serious s/e
QUESTION
MAOI mech of action
Answer:
block enzymes responsible for the breakdown of 5HT, NE, DA
- 2 primary forms of MAOI enzyme (MAOI-A and MAOI-B)
-both are located in brain
-MAOI-B is also located in gut
QUESTION
MAOI-A
Answer:
A = Antidepressant and Axiolytic
QUESTION
MAOI-B
Answer:
responsible for breakdown of DA, phenylephrine, and tyramine
-most MAOI-B meds are used in parkinsons
-high dose selegiline can be used in anxiety or depression
QUESTION
MAOI drugs
Answer:
phenelzine selegiline
tranylcypromine isocarboxazid
QUESTION
MAOI s/e
Answer:
confusion, dizziness, insomnia, sedation, vivid dreams
QUESTION
MAOI key points
Answer:
-clients taking MAOIs are at high risk for hypertensive crisis if tyramine is ingested
-do not prescribe any serotonergic agents within 2 weeks of MAOI discontinuation due to
increased risk of serotonin syndrome (wait at least 5 half lives)
QUESTION
MAOI pt edu
Answer:
important dietary restrictions
-foods that contain tyramine should be avoided
---red wine, sauerkraut, aged cheese, soy, smoked meats, preserved foods, tap and unpasteurized
beers, smoked fish, kimchee, tofu
- avoid these because MAOIs break down tyramine in the guy, ingesting extra tyramine can put
pt at risk for hypertensive crisis
QUESTION
SARI mech of action
Answer:
-serotonin antagonist and reuptake inhibitor
-potently blocks serotonin, allowing more 5HT to interact at postsynaptic sites
-trazadone
-trazadone also blocks histamine and alpha adrenergic receptors
QUESTION
trazadone
Answer:
used as adjunct for clients with MDD who cannot sleep short half life
traZZZZadone
QUESTION
trazadone s/e and edu
Answer:
priapism (a medical emergency!), educate pt to take at bedtime bc of sedation
-off label use for insomnia and anxiety
QUESTION
TCAs MOA
Answer:
possess both SRI and NRI properties but also block a-adrenergic, histamine, and muscarinic
receptors
QUESTION
TCA adverse effects
Answer:
-not 1st line treatment bc of high incidence of adverse rxns and potential risks of OD and death
-anticholinergic (cant see, cant pee, cant shit, cant spit)
-histamine effects (weight gain, sedation)
-alpha -1 adrenergic effects (orthostatic hypotension)
QUESTION
TCA drugs
Answer:
amitriptyline desipramine
doxepin imipramine nortriptyline
QUESTION
SNRI MOA
Answer:
inhibits 5HT and NE reuptake (increasing energy and focus). increase DA in the PFC
(increasing cognition)
QUESTION
SNRI pt education
Answer:
do not stop abruptly to avoid discontinuation [Show Less]