MMSC 409 Exam 3 - Complete Solutions (Answered) What is the Ag frequency for Le (a+b-) 22% What is the Ag frequency for Le (a-b+) 72% white, 55% black
... [Show More] What is the Ag frequency for Le (a-b-) 6% white, 22% black What is the Ag frequency for Le (a+b+) rare; because b outcompetes a for RBC adsorption site What is the Ag frequency for Fy(a) 65% What is the Ag frequency for Fy(b) 80% What is the Ag frequency for Fy (a+b+) white (49%), African American (1%), Chinese (8.9%) What is the Ag frequency for Fy (a+b-) Chinese (90.8%), White (17%), African American (9%) What is the Ag frequency for Fy (a-b+) 34% white, 22% African American 0.3% Chinese What is the Ag frequency for Fy (a-b-) 68% in African Americans, very rare in white, 0% in Chinese What is the Ag frequency for Jk(a) 77% What is the Ag frequency for Jk(b) 73% What is the Ag frequency for D? 85% What is the Ag frequency for C? 68% What is the Ag frequency for c? 80% What is the Ag frequency for E? 29% What is the Ag frequency for e? 98% What is the Ag frequency for Jk (a-b-) exceedingly rare most common in pacific islanders What is the Ag frequency for Jk (a+b+) White (49%) African American (34%) What is the Ag frequency for Jk (a+b-) White (28%) African American (57%) What is the Ag frequency for Jk (a-b+) White (23%) African American (9%) What is the Ag frequency for K 9% What is the Ag frequency for k 98.8% What is the Ag frequency for K-k+ White: 90% African American: 96.5% **(most common) What are the Ag frequencies for Kp(a) and Js(a) low frequency What are the Ag frequencies for Kp(b) and Js(b) high frequency What is the Ag frequency for M? 78% What is the Ag frequency for N? 72% What is the Ag frequency for S? 55% What is the Ag frequency for s? 89% What is the Ag frequency for U? 100% What is the Ag frequency for U-? 1% of black population What is the Ag frequency for P1 (P1, P Ags) 80% white, 94% black What is the Ag frequency for I/i both high frequency Ags, inversely proportional to each other What is the Ag frequency for Lu (a) 8% What is the Ag frequency for Lu (b) 99.9% What Ags are a part of the Lewis blood group system? Le, Se, ABO All Le (a+b-) individuals are ________ sese (non secretors) The Lewis gene (Le) confers _____ Ag expression Le(a) What does it mean if someone has an lele genotype? NO Le antigen on RBCs What is the Se frequency? 78% If a patient is B POS and has LeLe Sese genotypes, what blood group soluble substances will be detectable in this patient's secretions? B, H, Le(b) Is Lewis Ab IgM or IgG? IgM In what genotype individuals do Lewis Abs occur? almost exclusively in Le(a-b-) individuals Even though Lewis Abs are often found in the serum of pregnant women, what do neonates type as? Why? Lewis Ab can't cross placenta (IgM), so even if slight IgG component - neonates type Le(a-b-) so, Lewis Abs NOT associated with HDFN When does Lewis Ag typing become reliable? Why? - not reliable til abt age 6 - In newborns, Lewis fucosyltransferase more active than secretor fucosyltransferase Eventually this switches if both secretor and Le genes are present When do Lewis Abs usually react in testing? Most in IS phase, few show agglutination 37C at 37C, rarely reactive at AHG phase When it comes to transfusion practices, how do we treat Lewis Abs? - Lewis antibodies generally not significant, so Antigen phenotyping not necessary - Crossmatching is most acceptable means of providing compatible red blood cell products to patients with Lewis antibodies - Transfused cells (regardless of Lewis phenotype) will routinely assume the Lewis phenotype of the recipient within 24 hours Are Duffy Abs IgM or IgG? What does this mean for HDFN and HTRs? IgG, rarely bind complement - associated with HDFN and HTRs When does Duffy Ag typing become reliable? Why? at birth, bc Ags are well-formed at birth What is the advantage of Fy (a-b-) genotype? malarial resistance in the African American population T/F: Duffy Ags are enzyme-destroyed
true! When do Duffy Abs usually react in testing? react best at AHG and 37C T/F: Duffy Abs can exhibit dosage True Are Kidd Abs IgM or IgG? What does this mean for HDFN and HTRs? IgG, bind complement Associated with HDFN and may cause HTRs (especially DELAYED HTRs) When does Kidd Ag typing become reliable? Why? at birth, bc Ags are well-formed at birth T/F: Kidd Ags are enzyme-destroyed false! Ab reactivity is strengthened by enzymes T/F: Kidd Ags are strong immunogens false! they are poor immunogens What is the theory of inheritance for the rare Jk (A-b-) genotype? JkJk inheritance of silent gene from both parents In(Jk): inhibitor gene not allowing for antigen expression, does NOT form anti-Jk3 anti-Jk3: reacts with all Jk pos cells T/F: Kidd Abs can exhibit dosage True Are K Abs IgM or IgG? What does this mean for HDFN and HTRs? IgG, don't bind complement associated with SEVERE HDFN and HTRs When does K Ag typing become reliable? Why? at birth, bc Ags are well-formed at birth T/F: K Ags are enzyme-destroyed - K Ag is NOT denatured by ficin and papain (proteolytic enzymes) - K Ag IS destroyed by 2-ME, AET, DTT and ZZAP T/F: K Ags are strong immunogens true! (right after D Ag) T/F: K Abs can exhibit dosage False [Show Less]