MMSC 409 Exam 1 - Complete Solutions (Answered) Will Smith types as B POS and wants his family to donate blood for his upcoming surgery. His children fro... [Show More] m his marriage to Jada Pinkett Smith wish to donate. Jada types A POS. What ABO types could their children be? A, B, AB, O Will Smith types as B POS and wants his family to donate blood for his upcoming surgery. The surgeon would like to have 2 RBC available for him during surgery. Which of the following family members are a good match for Mr. Smith? Jaden Smith (A POS) Willow Smith (AB POS) Trey Smith (O POS) (his anti-A antibodies will attack A antigens in type A or AB) If a person in the family wants to donate both units needed for Mr. Smith's surgery, what type of donation is this? Directed If the person chosen wants to donate both units needed for Mr. Smith's surgery, and surgery is in 2 weeks, what method of donation could be used? Donate 2 RBC by apheresis technique, make AS-1 RBC's from these If the units are donated by Trey Smith to Will Smith, what additional processing needs to occur before they can be used for Will Smith? The units must be irradiated Trey Smith donates 2 RBCs by apheresis on 3/4/24. The AS-1 units are irradiated on 3/6/24 for surgery scheduled on 3/20/24, but surgery gets postponed to 3/30/24. What is the expiration of the 2 RBCs at this time? (March has 31 days) 4/3/2024 Prospective male donor: BP 170/90 temp 38C weight 125 lbs can he donate? NO! temp >37.5C Prospective female donor: Tattoo 2 years ago miscarriage 3 months ago
travelled to Africa for a safari 3 years ago can she donate? Yes Prospective donor: acupuncture 14 months ago had malaria in army 14 years ago tried to donate 14 days ago but hemoglobin was 12.4 g/dL can they donate? Yes, as long as hemoglobin is >12.5 today Which of the following are homozygous? C+, c-, E+, e+, Fya+, Fyb+, Jka-, Jkb+, M+, N- C, Jkb, M Antibodies to which of these show dosage? C+, c-, E+, e+, Fya+, Fyb+, Jka-, Jkb+, M+, N- All of them If mom is O and dad is B, what types can the children be? B or O If the child is AB and mom is B, what types can the father be? AA, AO, AB (A or AB) Are secretions antigens or antibodies? antigenic substances A patient has an anti-K antibody and an anti-c antibody and needs 3 RBCs for transfusion. How many RBCs must be screened for these antigens to find 3 antigen NEG units for a transfusion? frequency of K antigen = 9% frequency of c antigen = 80% 3/(0.91 x 0.20) = 16.5 RBCs or 17 RBCs bc we round up Where do RBCs go when they become rigid? RBCs removed by the spleen; if spleen is removed, membrane deformability decreases How is ATP generated? What do RBCs use it for? 90% generated thru glycolysis; used for energy and activating the Na/K pump What is spectrin? RBC protein that helps with flexibility and deformability a decrease in spectrin is due to a decrease in RBCs What happens to these factors during a left shift on the oxygen hemoglobin dissociation curve? oxygen affinity temp PCO2 2,3-DPG pH inc oxygen affinity dec temp dec PCO2 dec 2,3-DPG inc pH What causes a left shift of the oxygen hemoglobin dissociation curve? body temp decreases; blood sits in fridge What causes a right shift of the oxygen hemoglobin dissociation curve? exercise; high body temp; acidosis What happens to these factors during a right shift on the oxygen hemoglobin dissociation curve? oxygen affinity temp PCO2 2,3-DPG pH dec oxygen affinity inc temp inc PCO2 inc 2,3-DPG dec pH Explain the anticoagulants: CPD, CP2D, ACD-A in terms of components and expiration sodium citrate (anticoagulant), monobasic sodium phosphate (maintains pH), and dextrose (sustrate for ATP production) 21 day expiration Explain the anticoagulant CPDA-1 in terms of components and expiration sodium citrate, monobasic sodium phosphate, dextrose AND adenine (found in ATP, adds 2 weeks to exp) 35 day expiration What are the terms for AS-1-7? What do they do for CPDA-1? CPDA-1, centrifuged with plasma removed, with added components (within 72 hrs of centrifugation) Adsol (Baxter) AS-1 Nutricel (Pall) AS-3 Optisol (Terumo) AS-5 Salx (Haemonetics) AS-7 42 day expiration What test happens at both donor collection sites and transfusion service labs? Retyping segments from red cell units What institution does this describe? Voluntary inspection/accreditation of member institution labs, transplant services, *individuals AABB (Association for the Advancement of Blood & Biotherapies) What institution does this describe? Voluntary inspection/accreditation of member institution labs, transplant services, *not individuals CAP (College of American Pathologists) What institution does this describe? Voluntary inspection/accreditation of member institution labs, transplant services, whole hospitals or specific units Joint Commission What institution does this describe? Blood donor centers, rare donor registry, reference lab services American Red Cross What are the requirements for blood donors in terms of: weight temp pulse BP Hgb Hct weight: 110lbs temp: /=12.5 (females) or 13.0 g/dL (males) Hct: >/= 38% If a donor comes back negative for a donor blood Ab screen, what do we do? If they come back positive? negative: can use everything positive: can use RBCs, but cannot use plasma What is the benefit of using NAT (nucleic acid testing)? helps decrease window period where virus is present but not yet detectable List the infectious diseases we test donor blood for anti-HTLV I and II anti-HIV 1 and 2 HIV 1 Ag HBsAg and anti HBc anti HCV West Nile ALT T cruzi syphilis babesia What do we do if a donor sample comes back positive for an infectious disease? repeat the test 3 times. 2/3 positives = truly positive We can transfuse units that are positive for what, in relation to infectious diseases? anti-CMV positive units What is the STS test for? serological test for syphilis How long is the deferral for: anti-platelet meds 2-14 days How long is the deferral for: anticoagulants 2 days How long is the deferral for: heparin, warfarin, and coumadin 7 days How long is the deferral for: accutane (acne medication) 1 month How long is the deferral for: PEP pill vs injection pill: 3 months, injection: 2 years [Show Less]
