-Used to treat Parkinson's Disease
-Crosses the Blood Brain Barrier (unlike dopamine) and is decarboxylated to dopamine
-Given with a peripheral
... [Show More] decarboxylase inhibitor to permit lower dose and to lower nausea and vomiting side effects
-Side effects: orthostatic hypotension, sedation, confusion, hallucinations, psychosis
-Gold standard of treatment
Levo-dopa
Give with levodopa (Parkinsons)
Inhibits DOPA-decarboxylase in periphery-->increased levodopa in CNS
Carbidopa
Parkinsons
peripheral COMT inhibitor
Entacapone
Parkinsons
Peripheral COMT inhibitor
Tolcapone
Parkinsons
MAO-B inhibitor
Selegiline
MAO-B inhibitor used in parkinsons (just like selegeline)
Rasagaline
Parkinson's
Dopamine agonist
Bromocriptine
Parkinson's
Dopamine agonist
Pramipexole
Dopamine agonist (Parkinson's)
Ropinirole
Dopamine agonist (Parkinson's)
Rotigotine
Anticholinergic agent (Parkinson's)
Benztropine
Anticholinergic agent (Parkinson's)
Trihexyphenidyl
typical antipsychotic
high potency
blocks D1/D2 receptors
Haloperidol
typical antipsychotic
moderate potency
3 forms
Zuclopenthixol
typical antipsychotic
low potency
some sedative effects
Chlorpromazine
atypical antipsychotic
side effect of agranulocytosis
Clozapine
atypical antipsychotic
high potency
Risperidone
atypical antipsychotic
seems to halt schizophrenia progression
Olanzapine
atypical antipsychotic
lowest potency
cheapest
Quietapine
Alzheimers
monoclonal antibody against Aβ oligomers and aggregates, promising trials in treatment of AD.
Aducanumab
Anti-Alzheimer's
AchE inhibitor
Donepezil
Alzheimer's
AchE inhibitor
Galantamine
Alzheimer disease
AchE and butyrylcholinesterase inhibitor
Rivastigmine
Anti-Alzheimer's
NMDA antagonist, decreasing glutamate
for moderate-severe AD
Memantine
Depression
MAO-A Inhibitor; acts as a noradrenergic agonist
Moclobemide
tricyclic antidepressant
inhibits NE/serotonin reuptake
Imipramine
tricyclic antidepressant
inhibits NE/5HT reuptake
Desipramine
SNRI antidepressant
inhibit NE/5HT reuptake
Venlafaxine
SSRI antidepressant
inhibit 5HT reuptake
Fluoxetine
Atypical Antidepressant
presynaptic a2 receptor antagonist
Mirtazapine
bipolar disorder
prevent manic episode, mild antidepressant
Lithium
bipolar disorder & seizures & trigeminal neuralgia
decrease NaV channels
partial seizures
P450, enzyme inducer, self inducer
Carbamazepine
Anticonvulsant, bipolar
decrease Nav, potentiate GABA, block Ca, open Kv channels
partial and generalized seizure
heavy protein binding, displacing others
blocks liver metabolism (increase lamotrigine levels)
VPA levels decreased by P450 inducers
Valproic Acid [Show Less]