NSG 5003 WEEK 2 QUIZ / NSG5003 WEEK 2 QUIZ: ADVANCED PATHOPHYSIOLOGY-Hypersensitivity is best defined as a(an) - c.
Altered immunologic response to an
... [Show More] antigen that results in disease
A hypersensitivity reaction that produces an allergic response is called: - Anaphylaxis
The common hay fever allergy is expressed through a reaction that is mediated by which class of immunoglobulins? - IgE
Which type of antibody is involved in type I hypersensitivity reaction? - IgE
Blood transfusion reactions are an example of: - Alloimmunity
During an IgE-mediated hypersensitivity reaction, which leukocyte is activated? - c.
Eosinophils
During an IgE-mediated hypersensitivity reaction, the degranulation of mast cells is a result of which receptor action? - Histamine bound to H2
What characteristic do atopic individuals have that make them genetically predisposed to develop allergies? - c.
Greater quantities of IgE
What is the mechanism that results in type II hypersensitivity reactions? - d.
Antibodies bind to the antigens on the cell surface.
When mismatched blood is administered causing an ABO incompatibility, the erythrocytes are destroyed by - a.
Complement-mediated cell lysis
When antibodies are formed against red blood cell antigens of the Rh system, the blood cells are destroyed by: - Phagocytosis in the spleen
When soluble antigens from infectious agents enter circulation, tissue damage is a result of: - d.
Neutrophil granules and toxic oxygen products
How are target cells destroyed in a type II hypersensitivity reaction? - d.
Natural killer cells
Graves disease (hyperthyroidism) is an example of which type II hypersensitivity reaction? - Modulation
Type III hypersensitivity reactions are a result of which of the following? - b.
Antibodies binding to soluble antigens that were released into body fluids and the immune complexes being deposited in the tissues
A type IV hypersensitivity reaction causes which result? - .
Lymphokine-producing Th1 cells directly attacking and destroying cellular targets
In a type III hypersensitivity reaction, the harmful effects after the immune complexes that are deposited in tissues are a result of: - Complement activation
Raynaud phenomenon is classified as a type III hypersensitivity reaction and is due to: - a.
Immune complexes that are deposited in capillary beds, blocking circulation
Deficiencies in which element can produce depression of both B- and T-cell function? - Zinc
When the maternal immune system becomes sensitized against antigens expressed by the fetus, what reaction occurs? - Alloimmunity
Tissue damage caused by the deposition of circulating immune complexes containing an antibody against the host DNA is the cause of which disease? - Systemic lupus erythematosus
Why does tissue damage occurs in acute rejection after organ transplantation? - a.
Th1 cells release cytokines that activate infiltrating macrophages, and cytotoxic T cells directly attack the endothelial cells of the transplanted tissue. [Show Less]