Definition & General Causes of Infertility Correct Answer: fail conceive after specif time w/ reg interc w/o contrac (ie. 12 mts if <35y/o & 6mts if >35
... [Show More] or PCOS)
- 1/3 causes each fem orig, male orig, unk/combo of both partners
- conceiv prob decr 3-5%/yr after 30-32, faster after 37-40y/o by dim oocyte qual+quant
Pathophysiology, Sx, Labs, Causes, Solution for WHO Group I Infertility Correct Answer: - Pathophys = hypogonadotr hypogon by hypoth-pit fail
- Sx/labs = amen, low FSH/LH, low estrad, +/- elev prolactin
- Causes = eating disords, wt/exerc extremes, hyperprol
- Soln = correct cause (ie. gain wt, thyr med, dopa ag); reg Gn & ind ovul
Pathophysiology, Sx, Labs, Causes, Solution for WHO Group II Infertility Correct Answer: - Pathophys = normogonadotr anov by hypoth-pit-ovar fail **MOST COMMON**
- Sx/labs = nl FSH, nl-elev LH, nl estrad, elev PRL, galactorr
- Causes = PCOS, ovul-rel dysfunc, hyperPRL
- Soln = meds ind ovul, Gn to reg ovul, decr PRL by Dopa ag
Pathophysiology, Sx, Labs, Causes, Solution for WHO Group III Infertility Correct Answer: - Pathophys = hypergonadotr hypogon by ovar fail
- Sx/labs = elev FSH, low estrad
- Causes = adv age
- Soln = oocyte don, IVF
Other causes of Infertility Correct Answer: ut/outfl tract abnorms, tub dis by PID
- Treat w/ meds/IVF
Pathophysiology, Sx, Labs, Causes, Solution for Male Factor Infertility Correct Answer: - Pathophys = anat vars, chrom abnorms, erec/ejac dysf
- Sx/labs = abnl FSH/LH, testost, semen analysis
- Causes = inf, inj, tox expos, syst dis, sperm ABs, hypogon, testic dis, sperm transp defs
- Soln = IVF, intraut insem, don sperm
**MOST COMMON CAUSE is cryptorch**
Overview of Repro Endocrinology Correct Answer: hypoth secr GnRH stim ant pit gonadotropins LH+FSH stim ovars+testes
- -reg by inhibin (-FSH) & elev estrog/progest/testost (-GnRH+LH/FSH)
- +reg by activin (+FSH) & estrog (+LH/FSH mid-cyc)
Role of Gonadotropins in Menstrual Cycle Correct Answer: - Follic ph (prolif ph) = low estrog/inhib --> elev LH/FSH stim follic dev for dom foll form; high sust estrog, mid-cyc LH/FSH surge for ovul
- Luteal ph (secr ph) = corp lut secr estrog+progest, endom prep for implant by progest incr blood supp spir arts
**ovar dysf accounts for most infert cases** [Show Less]