WGU BioChemistry C785 Exam Review 170 (Q/A) Latest 2022
Match the letters with the correct names of the processes of the central dogma (Replication;
... [Show More] Transcription; Translation). A) Replication, B) Transcription, C) Translation 2. Label the lettered strands of nucleic acid below. The possible words to use in labeling strands are: Coding Strand, Non- template Strand, Non-coding Strand, Template Strand, and mRNA. Note: A and B refer to one strand of DNA; C and D refer to the other strand of DNA. A) Non-template B) Coding C) Template D) Non-coding E) mRNA 3. If one strand of chromosome 2 has a DNA sequence that consists of this: 5’ AAG CGG TAC GTA 3’ What will be the composition of the complementary DNA strand? (Select all that apply) 3' TTC GCC ATG CAT 5' & 5'TAC GTA CCG CTT 3' 4. During DNA replication, which of the following sequences can be used as a primer for the following DNA sequence: 3' AGT GGA TCA CTA GGC TCT 5'? (Recall that DNA replication uses RNA primers whereas PCR uses DNA primers). 5' UCA CCU AGU GAU 3' 5. Which of the following is the correct tRNA anticodon for the mRNA codon 5' GCA 3' ? 5' UGC 3' 6. The following sequence is the coding DNA strand of the collagen gene: 5’ ATG GCG TTC GAA 3’ What is the sequence of the corresponding mRNA? 5' AUG GCG UUC GAA 3' 7. What would be the resulting mRNA sequence from a template strand with this sequence: 5’-CAG CTC GTC-3’? 5’-GAC GAG CUG-3’ 8. What is the coding strand sequence if the non-template strand sequence is 5’-AGC CTT TAA CTA-3’ 3’-ATC AAT TTC CGA-5’ 9. What would be the amino acid sequence that would result from this template sequence: 5'-TGC AAG CCA-3’? Trp Leu Ala 10. What would the amino acid sequence be from this coding strand sequence: 5’-GGA AGG CCC-3’ (utilize the table from question 9)? Gly Arg Pro 11. A mutation in the DNA that changes the sequence of a codon but does NOT change the amino acid sequence of the protein describes a _____ _____. silent mutation. 12. A nonsense mutation changes a codon to introduce a premature stop codon 13. Point mutations change a single nucleotide in a mutant gene compared to the normal gene. Examples are missense, nonsense, and silent mutations. 14. A missense mutation changes a single amino acid in a protein. 15. Frameshift mutations change the number of nucleotides in a mutant gene compared to the normal gene. Examples are insertion and deletion mutations. 16. When comparing a normal and mutant gene sequence, how do you identify a frameshift mutation? The number of nucleotides between the normal and mutant gene sequences is different and the amino acid sequence is different. 17. If the coding (non-template) DNA sequence of a normal gene is 5' GTC GCA TGG TGA 3', what kind of mutation would create the mutant gene sequence 5' GTC GAC ATG GTG A 3'? Insertion mutation 18. If the coding (non-template) DNA sequence of a normal gene is 5' GTC GCA TGG TGA 3', which DNA sequence would represent a nonsense mutation (utilize table from question 17)? 5' GTC GCA TAG TGA 3' 19. If the coding (non-template) DNA sequence of a normal gene is 5' GTC GCA TGG TGA 3', which DNA sequence would represent a deletion mutation (utilize table from question 17)? 5' GTC GCA TGT GA 3' 20. Which of the following would be considered a point mutation to a DNA strand that consists of a nucleotide sequence: 5’ CTG ACG TAT CTT AAT 3’ (utilize table from question 17)? 5’ CTG ACG TAA CTT AAT 3’ 21. The RNA sequence 5’-CUC AUA GCC UGA CCC-3’ is mutated to 5’-CUC AUA GCC UAA CCC-3’ What kind of mutation is this? (utilize table from question 17) Silent 22. 12. The following is the mRNA sequence for actin, a protein that provides structure to a cell: 5’ ACU AGA CGU UUU UAA 3’. A mutation to the actin gene results in the production of the following mRNA: 5’ ACU AGA CAU UUU UAA 3’ What type of mutation is this? (utilize table from question 17) Missense 23. Sickle Cell Anemia is inherited in an autosomal recessive pattern. Choose the set of chromosomes of a person that has inherited the disease. Green boxes represent normal alleles and yellow boxes represent mutant alleles. D 24. Hemophilia is an X-linked recessive condition. This means that: A person with at least one normal X chromosome without the hemophilia gene will not show signs of hemophilia 25. A woman is homozygous for an abnormal allele on Chromosome 2 that codes for an autosomal dominant disease. This means that she: Will have the disease 26. Mutations in the FANCA gene (located on chromosome 16) can lead to Fanconi Anemia. A healthy individual inherited one mutant and one normal allele of the FANCA gene. Which of the following describes the inheritance pattern of Fanconi Anemia? Autosomal Recessive 27. A black female mouse mates with a white male mouse and produces a litter of all gray mice. Which inheritance pattern can be used to describe this situation? Incomplete Dominance 28. Two healthy individuals give birth to a child that has Bloom Syndrome. From this information, it can be concluded that Bloom syndrome is inherited in a ________ [Show Less]