Walden NURS 6630 Psychopharmacology Study Guide
The chemical basis of neurotransmission - ANS-is how chemical signals are coded, decoded, transduced,
... [Show More] and sent along the way.
The anatomical basis of neurotransmission - ANS-is neurons and the connections between them, called synapses, sometimes also called the anatomically addressed nervous system, a complex of "hard-wired" synaptic connections between neurons, not unlike millions of telephone wires within thousands upon thousands of cables
The cytochrome P450 (CYP) enzyme system - ANS-mediates how the body metabolizes many drugs, including antipsychotics.
The CYP enzyme - ANS-in the gut wall or liver converts the drug into a biotransformed product in the bloodstream. After passing through the gut wall and liver, the drug will exist partly as unchanged drug and partly as biotransformed drug.
agonist - ANS-produces a conformational change in the G-protein-linked receptor that turns on the synthesis of second messenger to the greatest extent possible
full agonist - ANS-is generally represented by the naturally occurring neurotransmitter itself, although some drugs can also act in as full a manner as the natural neurotransmitter
Constitutive activity - ANS-in the absence of agonist, the receptor's conformation is such that it leads to a low level of activity
Antagonists - ANS-blocks agonists (both full and partial) from binding to G-protein-linked receptors, thus preventing agonists from causing maximum signal transduction and instead changing the receptor's conformation back to the same state as exists when no agonist is present
classic synaptic neurotransmission - ANS-stimulation of a presynaptic neuron (e.g., by neurotransmitters, light, drugs, hormones, nerve impulses) causes electrical impulses to be sent to its axon terminal. These electrical impulses are then converted into chemical messengers and released to stimulate the receptors of a postsynaptic neuron.
The synaptic cleft - ANS-is the gap between the presynaptic neuron and the postsynaptic neuron; it contains proteins and scaffolding and molecular forms of "synaptic glue" to reinforce the connection between the neurons. Receptors are present on both sides of this cleft and are key elements of chemical neurotransmission.
the soma - ANS-is the command center of the nerve and contains the nucleus of the cell
axon - ANS-Neurons send information via an ____ that forms presynaptic terminals as the ____ passes by (en passant) or as the ____ ends
axodendritic - ANS-synaptic connections between the axon and dendrites of two neurons [Show Less]