1. Serotonin regulates: Mood, emotion, feeding, and reproductive behavior
2. This class of antidepressants binds to presynaptic SERT and inhibits them
... [Show More] from reuptake of serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors: SSRIs
3. First line therapy for MDD due to milder side effect profiles: SSRIs
4. Six Common SSRIs: citalopram, escitalopram, fluoxetine, fluvoxamine, sertra- line, paroxetine
5. Onset of therapeutic benefit from SSRIs: 4-6 weeks
6. In addition to MDD, SSRIs also treat: Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia)
7. Five Common side effects of SSRIs include: Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH
8. Severe side effect of SSRIs in children/adolescents under age 25 years old: suicidal ideation
9. Life threatening adverse effect of SSRIs, especially when used in combi- nation with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.): Serotonin Syndrome
10. Excess accumulation of serotonin resulting in overstimulation of the nervous system: Serotonin Syndrome
11. Seven symptoms of Serotonin Syndrome: Flushing, hyperthermia, agita- tion, muscle rigidity, seizure, coma, HYPERreflexia
12. The treatment for serotonin syndrome: Cyproheptadine (5-HT2 receptor antagonist)
13. Cyproheptadine treats serotonin syndrome by: blocking 5-HT2 receptors (serotonin antagonist)
14. When SSRIs or SNRIs are stopped abruptly, common symptoms of with- drawal include: Irritability, headaches, and insomnia
15. Medicine specific side effect of citalopram: Prolonged QT interval (nor- mal=0.4.-0.44 seconds)
16. This SSRI is pregnancy category D due to associations with congenital heart defects: Paroxetine
17. All SSRIs but paroxetine (D) are pregnancy category: C
18. Three SSRIs that are inhibitors of Cytochrome P450 enzymes: fluoxetine, fluvoxamine, and paroxetine
19. Five common SNRIs include: duloxetine, venlafaxine, desvenlafaxine, mil- nacipran, levomilnacipran
20. This antidepressant class of medications works by binding to presynap- tic SERT a [Show Less]