UTMB ADVANCED PATHOPHYSIOLOGY 5355 EXAM 3 MODULES 5 & 6 Already Passed!!
Biogenic Amine Theory linked to depression - Deficiency of
neurotransmitters in
... [Show More] brain of norepinephrine, dopamine, and/or serotonin.
Particularly, a decrease in receptor binding with serotonin.
Neurotransmitter Receptor Hypothesis linked to depression - A deficiency
of monoamine neurotransmitters at neuronal synapses.
Antidepressants increase - Neuronal synaptic levels of monoamine
neurotransmitters.
if you have more receptors than neurotransmitters - Neurotransmitters do
not have time to re-charge thus, they do not function properly.
Hypothalamic-Pituitary-Adrenal (HPA) System Dysregulation - HPA system
dysregulation with excessive glucocorticoid secretion is found in a large
percentage of people suffering from major depression.
Patho of Alzheimer's includes - plaque formation, presence of --, with
decreased levels of - - Amyloid B, neurofibrillary tangles, acetylcholine
these disrupt impulse transmission
neurofibrillary tangles - are a deformation of the structure that carries
nutrients to neurons of the brain.
Decreased levels of choline acetyl transferase and acetylcholine is
associated with - Memory loss
Most common cause of dementia - Alzheimer's disease fatal 5-10 years
Characteristics of Alzheimer's - Loss of memory, language , inability to
learn new things, dysfunction, delusions, cannot perform ADLs, majorly
effects social life
UTMB ADVANCED PATHOPHYSIOLOGY 5355
EXAM 3 MODULES 5 & 6 Already Passed!!
Parkinson's Disease is - Chronic motor progressive neuro-degenerative
known as a shaking palsy
Parkinson's disease is associated with - basal ganglia dysfunction and
atrophy of neurons in the substantia nigra that produce dopamine;
Characteristics of Parkinson's disease - Tremors at rest, rigidity,
bradykinesia, muscular rigidity and postural abnormalities.
2 Main Categories of CVA - Hemorrhagic and Ischemic
Hemorrhagic CVA - Blood produces inflammatory reaction, swelling,
displaces brain tissue and increases ICP
2 types of hemorrhagic stroke - Intracerebral and subarachnoid
Intracerebral Hemorrhage - Blood vessel leaks directly into brain tissue
Subarachnoid hemorrhage - Bleeding into the subarachnoid space, caused
by trauma, aneurysm rupture presents as "worst headache of life". surgical
emergency
Ischemic CVA - reduction in cerebral blood flow results in hypoxia and
irreversible cell death with associated cerebral edema
3 types of ischemic CVA - thrombotic, embolic, hypercoagulable states.
Thrombotic - caused by atherosclerosis blocking vessels. obstruction of
blood vessel due to localized occlusive process
Embolic - caused by blood clot, fat or air embolus traveling from distant site
to brain
Hypercoaguable state - conditions such as sickle cell disease,
polycythemia causing blood clot to form and obstruct vessel . [Show Less]