Test Bank Huether and McCance: Understanding Pathophysiology, 5th Edition
Table ofContents
Chapter 01: Cellular Biology ................................
... [Show More] ................................ .......... 2 Chapter 02: Genes and Genetic DiseasesTest Bank................................ ....................... 18 Chapter 03: Altered Cellular and TissueBiology ................................ ......................... 31 Chapter 04: Fluids and Electrolytes, Acids andBases ................................ ..................... 46 Chapter 05: Innate Immunity: Inflammationand Wound Healing ................................ ........... 61 Chapter 06: Adaptive Immunity ................................ ................................ ...... 79 Chapter 07: Infection and Defects inMechanisms of Defense................................ ............... 90 Chapter 08: Stress and Disease ................................ ................................ ...... 109 Chapter 09: Biology, Clinical Manifestations,and Treatment of Cancer ................................ ..... 116 Chapter 10: Cancer Epidemiology ................................ ................................ .... 123 Chapter 11: Cancer in Children ................................ ................................ ...... 130 Chapter 12: Structure and Function of theNeurologic System................................ ............. 133 Chapter 13: Pain, Temperature, Sleep, and ................................ ............................ 150 Chapter 15: Disorders of the Central andPeripheral Nervous Systems and the Neuromuscular Junction......... 181 Chapter 16: Alterations of Neurologic Functionin Children................................ ............... 203 Chapter 17: Mechanisms of HormonalRegulation................................ ....................... 214 Chapter 18: Alterations of HormonalRegulation ................................ ........................ 229 Chapter 19: Structure and Function of theHematologic System ................................ ........... 251 Chapter 20: Alterations of HematologicFunction ................................ ....................... 262 Chapter 21: Alterations of HematologicFunction in Children ................................ ............. 288 Chapter 23: Alterations of Cardiovascular ................................ ............................. 324 Chapter 24: Alterations of Cardiovascular ................................ ............................. 356 Chapter 25: Structure and Function of thePulmonary System ................................ ............ 367 Chapter 26: Alterations of Pulmonary Function ................................ ........................ 380 Chapter 27: Alterations of Pulmonary Functionin Children................................ ............... 401 Chapter 28: Structure and Function of theRenal and Urologic Systems................................ ..... 413 Chapter 29: Alterations of Renal and UrinaryTract Function ................................ ............. 425 Chapter 30: Alterations of Renal and UrinaryTract Function in Children ................................ ... 438 Chapter 31: Structure and Function of theReproductive Systems................................ .......... 447 Chapter 32: Alterations of the ReproductiveSystems Including Sexually Transmitted Infections ............... 461 Chapter 33: Structure and Function of theDigestive System ................................ .............. 476 Chapter 34: Alterations of Digestive Function................................ .......................... 488
1 | P a g eChapter 35: Alterations of Digestive Functionin Children ................................ ................ 512
Chapter 36: Structure and Function of theMusculoskeletal System ................................ ........ 526
Chapter 37: Alterations of Musculoskeletal ................................ ............................ 541
Chapter 38: Alterations of MusculoskeletalFunction in Children ................................ .......... 558
Chapter 39: Structure, Function, andDisorders of the Integument ................................ ......... 566
Chapter 40: Alterations of the Integument inChildren ................................ ................... 582
Chapter 01: Cellular Biology
MULTIPLE CHOICE
1. A student is observing a cell under the microscope. It is observed to have supercoiled DNA
with histones. Which of the following would also be observed bythe student?
a.
b.
A single circular chromosome
A nucleus
ANS: B
The cell described is a eukaryotic cell, so it has histones and a supercoiled DNAwithin its
nucleus; thus, the nucleus should be observed.
A single circular chromosome is characteristic of prokaryotic cells, which do not havehistones.
Free-floating nuclear material describes a prokaryotic cell, which would not have adistinct
nucleus.
Eukaryotic cells have membrane bounded cellular components called organelles. Noorganelles
describes a prokaryotic cell.
REF: p. 2
2. A nurse is instructing the staff about cellular functions. Which cellular function isthe nurse
describing when an isolated cell absorbs oxygen and uses it to transform nutrients to energy?
c.
d.
Free-floating nuclear material
No organelles
a.
b.
c.
Metabolic absorption
Communication
Secretion
ANS: D
The ability of the cell to absorb oxygen refers to the cell’s function of respiration.
The ability of the cell to function within a society of cells refers to its function of
communication.
The ability of the cell to take in nutrients refers to the cell’s function of metabolic
absorption.
The ability of the cell to synthesize new substances and secrete these elsewhere refersto the
d.
Respiration
2 | P a g ecell’s function of secretion.
REF: p. 3
3. A eukaryotic cell is undergoing DNA replication. In which region of the cell wouldmost of the
genetic information be contained?
Mitochondria
a.
b.
c.
Ribosome
Nucleolus
ANS: C
The region of the cell that contains genetic material, including a large amount ofribonucleic
acid, most of the DNA, and DNA-binding proteins, is the nucleolus. The mitochondria is the
site of cellular respiration.
The ribosomes are involved in manufacturing of proteins within the cell.
The nucleus contains the nucleolus, and it is the nucleolus that contains geneticmaterial.
REF: p. 5
4. The fluid mosaic model for biologic membranes describes membrane behavior. According
to this model, which of the following float singly or as aggregates in thefluid lipid bilayer?
d.
Nucleus
a.
b.
c.
Peripheral membrane proteins
Integral membrane proteins
Glycoproteins
ANS: B
Integral membrane proteins float freely in the fluid lipid bilayer.
Peripheral membrane proteins are not embedded in the layer, but reside at the surface.
Glycoproteins act as cell surface markers.
Cell adhesion molecules are on the outside of the membrane and allow cells to hooktogether.
REF: p. 6
5. Which of the following can bind to plasma membrane receptors?
a.
d.
Cell adhesion molecules
Oxygen
b.
c.
d.
Ribosomes
Amphipathic lipids
Ligands
ANS: D
Ligands are specific molecules that can bind with receptors on the cell membrane.Oxygen
moves by diffusion; it does not bind to receptors.
Ribosomes make proteins and are not involved in binding.
Amphipathic lipids are a portion of the cell membrane.
3 | P a g eREF: p. 11
6. A nurse is reviewing a report from a patient with metastatic cancer. What finding would
support the diagnosis of metastatic cancer? Alterations in extracellular matrixthat include:
a.
b.
c.
Decreased fibronectin
Increased collagen
Decreased elastin
ANS: A
Reduced amounts of fibronectin are found in some types of cancerous cells, allowingcancer cells
to travel, or metastasize.
Collagen provides strength, and its breakdown is associated with osteoarthritis, notcancer.
Elastin is found in the lungs and allows tissues to stretch; it is not associated withcancerous
cells.
Decreased, not increased, glycoproteins are associated with cancerous cells.REF: p. 8
7. Which form of cell communication is used to relate to other cells in direct physicalcontact?
d.
Increased glycoproteins
4 | P a g ea.
b.
c.
d.
Cell junction
Gap junction
Desmosomes
Tight junctions
ANS: A
Cell junctions hold cells together and permit molecules to pass from cell to cell.Gap
junctions allow communication from the inside of one cell to the inside of another.
Desmosomes are not involved in communication, but allow cells to hold together. Tight
junctions are barriers that prevent movement of some substances and leakagesof others.
REF: p. 9
8. Pancreatic beta cells secrete insulin, which inhibits secretion of glucagon from neighboring
alpha cells. This action is an example of which of the following signalingtypes?
a.
b.
Paracrine
Autocrine
ANS: A
Paracrine signaling involves the release of local chemical mediators that are quickly taken up,
destroyed, or immobilized, as in the case of insulin and the inhibition of thesecretion of
glucagon.
When cells produce signals that they themselves respond to, autocrine signaling isused.
Neurohormonal signaling involves secretion of hormones into the bloodstream by
neurosecretory hormones.
Hormonal signaling involves specialized endocrine cells that secrete hormone chemicals
released by one set of cells that travel through the tissue through thebloodstream to
produce a response in other sets of cells.
REF: p. 11
9. In cellular metabolism, each enzyme has a high affinity for a:
c.
d.
Neurohormonal
Hormonal
5 | P a g ea.
b.
c.
d.
Solute
Substrate
Receptor
Ribosome
ANS: B
Each enzyme has a high affinity for a substrate, a specific substance converted to aproduct of
the reaction.
Solutes are small particles that pass through the cell membrane.
A receptor is a site on the cell wall that allows transport into the cell.
Ribosomes are located inside the cell and are not related to the work of enzymes.REF: p. 13
10. An athlete runs a marathon, after which his muscles feel fatigued and unable tocontract.
The athlete asks the nurse why this happened. How should the nurse
respond? A deficiency in
can cause impaired muscle contraction.
a.
b.
c.
d.
GTP
AMP
ATP
GMP
ANS: C
The cell uses ATP for muscle contraction. when it is deficient, impaired musclecontraction
results.
GTP is involved in cell signaling, not muscle contraction.AMP is
not involved in muscle contraction.
GMP is not involved in muscle contraction.REF: p.
13
11. Which phase of catabolism produces the most ATP?
a.
Digestion
b.
c.
d.
Glycolysis
Oxidation
Citric acid cycle
ANS: D
Most of the ATP is generated during the citric acid cycle.
Larger molecules are broken down into smaller units during digestion; no ATP isproduced
during this cycle.
During glycolysis, two molecules of ATP are produced from each glucose molecule,but the most
ATP is produced during the citric acid cycle.
Oxidation is part of the glycolysis process and ATP is produced, but more ATP isproduced
6 | P a g eduring the citric acid cycle.
REF: p. 13
12. A nurse is teaching the staff about the three phases of cellular catabolism. Whichof the
following should the nurse include?
a.
b.
c.
ANS: A
Digestion, glycolysis and oxidation, and the citric acid cycle are the three phases ofcellular
catabolism.
Diffusion, osmosis, and mediated transport are parts of the movement of fluids in andout of cells.
The S, G, and M phases are phases of cellular division, not catabolism. Metabolic
absorption, respiration, and excretion are functions of the cell.REF: p. 13
13. A runner has depleted all the oxygen available for muscle energy. Which of thefollowing
will facilitate his continued muscle performance?
Digestion, glycolysis and oxidation, and the citric acid cycle
Diffusion, osmosis, and mediated transport
S phase, G phase, and M phase
d.
Metabolic absorption, respiration, and excretion
a.
b.
c.
d.
Electron-transport chain
Aerobic glycolysis
Anaerobic glycolysis
Oxidative phosphorylation
ANS: C
When no oxygen is available, anaerobic glycolysis occurs. The
electron-transport chain is part of the citric acid cycle. Aerobic
glycolysis involves the presence of oxygen.
Oxidative phosphorylation is the mechanism by which the energy produced from
carbohydrates, fats, and proteins is transferred to ATP. It is not part of muscle performance.
REF: p. 14
14. The faculty member asked the student to identify the appropriate term for the
movement of small, electrically uncharged molecules through a semipermeable barrier.
Which answer indicates the nursing student understood the teaching?
a.
b.
c.
Osmosis
Diffusion
ANS: B
Diffusion is the movement of a solute molecule from an area of greater solute
concentration to an area of lesser solute concentration.
Osmosis is the movement of water across a semipermeable membrane from a regionof higher
water concentration to one of lower concentration.
Hydrostatic pressure
d.
Active transport
7 | P a g eHydrostatic pressure is the force of fluid against a cell membrane. Within the vascularsystem, this
pressure is the blood pressure.
In active transport, molecules move up a concentration gradient. This process requiresenergy.
REF: p. 15
15. A nurse is teaching a patient about fluid and electrolytes. Which of the followingindicates
the teaching was successful regarding electrolytes? Electrolytes are:
a.
b.
c.
d.
Small lipid-soluble molecules
Large protein molecules
Micronutrients used to produce ATP
Electrically charged molecules
ANS: D
Electrolytes are electrically charged molecules.
Electrolytes are not lipid soluble.
Electrolytes are not made up of protein.
Electrolytes do not have a role in the production of ATP.
REF: p. 15
16. A nurse is reading a chart and sees the term oncotic pressure. The nurse recallsthat
oncotic pressure (colloid osmotic pressure) is determined by:
a.
b.
c.
Concentration of sodium
Plasma proteins
ANS: B
Oncotic pressure is determined by the effect of colloids or plasma proteins.The
concentration of sodium plays a role in tonicity.
Hydrostatic pressure is the force within a vessel.
Membrane transporter proteins are involved in active transport within a concentrationgradient.
REF: p. 16
17. A patient has a body fluid of 300 mOsm/kg. This lab result is measuring:
a.
Hydrostatic pressure
d.
Availability of membrane transporter proteins
Osmolality
b.
c.
d.
Osmolarity
Osmotic pressure
Oncotic pressure
ANS: A
Osmolality measures the number of milliosmoles per kilogram of water, or the
concentration of molecules per weight of water.
Osmolarity measures the number of milliosmoles per liter of solution, or the
8 | P a g econcentration
of molecules per volume of solution.
Osmotic pressure is the amount of hydrostatic pressure required to oppose the osmoticmovement
of water.
Oncotic pressure is from plasma proteins, not body fluids.REF: p.
16
18. In teaching a patient with cirrhosis, which information should the nurse includeregarding
cholesterol?
b.
c.
d.
Cholesterol decreases the membrane fluidity of erythrocytes, which reduces its ability to c
Cholesterol increases the membrane fluidity of erythrocytes, which allows binding of exce
Cholesterol increases the membrane fluidity of erythrocytes, which prolongs its life span b
a.
Cholesterol decreases the membrane fluidity of the erythrocyte, which reduces its ability t
ANS: A
In cirrhosis, the cholesterol content of the red blood cell’s plasma membrane increases,
causing a decrease in membrane fluidity that seriously affects the cell’sability to transport
oxygen.
In cirrhosis, for example, the cholesterol content of the red blood cell’s plasma membrane
increases, causing a decrease in membrane fluidity that seriously affectsthe cell’s ability to
transport oxygen, not hemoglobin; the hemoglobin carries the oxygen.
In cirrhosis, for example, the cholesterol content of the red blood cell’s plasma membrane
increases, causing a decrease in membrane fluidity that seriously affectsthe cell’s ability to
transport oxygen; it does not bind excess glucose.
In cirrhosis, for example, the cholesterol content of the red blood cell’s plasma membrane
increases, causing a decrease in membrane fluidity that seriously affects the cell’s ability to
transport oxygen. It does not prolong the life of the RBC and coulddecrease it.
REF: p. 7
19. A nurse is discussing the movement of fluid across the arterial end of capillary membranes
into the interstitial fluid surrounding the capillary. Which process of fluidmovement is the nurse
describing?
a.
b.
c.
Hydrostatic pressure
Osmosis
ANS: A
Blood reaching the capillary bed has a hydrostatic pressure of 25 to 30 mm Hg, whichis sufficient
force to push water across the thin capillary membranes into the interstitial space.
Osmosis involves the movement of fluid from an area of higher concentration to anarea of
lower concentration. It does not involve pressure or force. It is related to hydrostatic pressure.
Diffusion is the passive movement of a solute from an area of higher solute
concentration to an area of lower solute concentration.
Active transport involves movement up a concentration gradient.REF: p.
Diffusion
d.
Active transport
9 | P a g e16
20. A patient who has diarrhea receives a hypertonic saline solution intravenously toreplace
the sodium and chloride lost in the stool. What effect will this fluid replacement have on cells?
a.
b.
Cells will become hydrated.
Cells will swell or burst.
ANS: C
The hypertonic saline will cause fluid to leave the intracellular space and enter thevascular
space, causing cells to shrink.
Intravenous hypertonic solutions lead to cell dehydration.
Intravenous hypertonic solutions cause fluid to leave cells; thus, they would shrink,not swell.
Intravenous hypertonic solutions do not affect cellular division.REF: p.
17
21. A nurse is teaching a patient with diabetes how glucose is transported from theblood to
the cell. What type of transport system should the nurse discuss with the patient?
c.
d.
Cells will shrink.
Cells will divide.
a.
b.
c.
Active-mediated transport (active transport)
Active diffusion
Passive osmosis
ANS: D
A well-known passive-mediated transport system is that for glucose in erythrocytes(red blood
cells).
The transport of glucose does not require energy, so active-mediated transport is notcorrect.
The transport of glucose does not require energy, so active diffusion is not correct.
Osmosis involves the movement of water.REF:
p. 17
22. How are potassium and sodium transported across plasma membranes?
a.
d.
Passive-mediated transport (facilitated diffusion)
By passive electrolyte channels
b.
c.
d.
By coupled channels
By adenosine triphosphate enzyme (ATPase)
By diffusion
ANS: C
A “carrier” mechanism in the plasma membrane mediates the transport of ions andnutrients.
The best-known pump is the Na+-K+–dependent ATPase pump.
Electrolyte movements require energy and do not move passively.
Enzymes, not electrolytes, are passed via coupled channels.
Electrolytes are not transported by diffusion.REF:
10 | P a g ep. 17
23. Why is potassium able to diffuse easily in and out of cells?
a.
Because potassium has a greater concentration in the intracellular fluid (ICF)
b.
c.
d.
Because sodium has a greater concentration in the extracellular fluid (ECF)
Because the resting plasma membrane is more permeable to potassium
Because there is an excess of anions inside the cell
ANS: C
The resting membrane is more permeable to potassium because potassium is moreeasily
transported inward.
Potassium is greater in concentration in the ICF, but this is not why it is transportedmore
easily.
Sodium does have a greater concentration, but this is not why potassium moves easilywhen the
membrane potential is at rest.
It is cations, not anions, that are involved in membrane potential activity.REF: p.
18
24. The ion transporter that moves Na+ and Ca2+ simultaneously in the samedirection
is an example of which of the following types of transport?
a.
Biport
b.
Uniport
11 | P a g ec.
d.
Antiport
Symport
ANS: D
When ions are transported in one direction, it is termed symport.There
is no such term as biport.
Uniport refers to the movement of a single molecule.
Antiport refers to movement of molecules in the opposite direction.REF: p.
17
25. During which process can lysosomal enzymes be released to degrade engulfedparticles?
a.
b.
Endocytosis
Pinocytosis
ANS: C
Engulfment of particles occurs by phagocytosis.
Endocytosis involves the formation of vesicles to facilitate movement into the cell. Pinocytosis is
a type of endocytosis in which fluids and solute molecules are ingestedthrough formation of
small vesicles.
Exocytosis occurs when coated pits invaginate and internalize ligand-receptorcomplexes
in coated vesicles.
REF: p. 20
26. A nurse is teaching the staff about cholesterol. Which information should betaught?
The cellular uptake of cholesterol depends on:
c.
d.
Phagocytosis
Exocytosis
a.
b.
c.
d.
Active-mediated transport
The antiport system
Receptor-mediated endocytosis
Passive transport
ANS: C
The cellular uptake of cholesterol depends on receptor-mediated endocytosis.
The cellular uptake of cholesterol depends on receptor-mediated endocytosis; it is notdependent
on active-mediated transport.
The cellular uptake of cholesterol depends on receptor-mediated endocytosis; it is nota part of
the antiport system.
The cellular uptake of cholesterol depends on receptor-mediated endocytosis; itrequires
energy and is not passive in transport.
REF: p. 20
27. Some cancer drugs work during the cell cycle phase where nuclear and
cytoplasmic division occurs. What is this cell cycle phase called?
12 | P a g e
a.
b.
c.
G1
S
MANS: C
The M phase includes both nuclear and cytoplasmic division.
The G1 phase includes the period between the M phase and the start of DNAsynthesis.
The S phase include synthesis of DNA in the cell nucleus.The G2
phase includes RNA and protein synthesis.
REF: p. 23
28. What causes the rapid change in the resting membrane potential that initiates anaction
potential?
a.
b.
c.
d.
Potassium gates open, and potassium rushes into the cell, changing the membrane potentia
to positive.
Sodium gates open, and sodium rushes into the cell, changing the membrane potential fro
positive.
Sodium gates close, allowing potassium into the cell to change the membrane potential fro
negative.
ANS: B
When the threshold is reached, the cell will continue to depolarize with no further
stimulation. The sodium gates open, and sodium rushes into the cell, causing the membrane
potential to reduce to zero and then become positive (depolarization). Sodium is involved in
creating the action potential, not potassium.
The sodium gate must be open, not closed.
The sodium channel must be open; this is not affected by a change in the potassiumgate.
REF: p. 21
29. A cell is isolated, and electrophysiology studies reveal that the resting membranepotential
is –70 millivolts. The predominant intracellular ion is Na+, and the predominant extracellular
ion is K+. With voltage change, which of the following would result in an action potential?
Potassium gates close, allowing sodium into the cell to change the membrane potential fro
negative.
a.
b.
ANS: A
With voltage change, potassium rushes into the cell.
Potassium, not sodium, rushes into the cell.
Potassium, not sodium, is involved in the process, and potassium moves into the cells,not out.
Potassium rushes into the cell, not out.REF:
K+ rushing into the cell
Na+ rushing into the cell
c.
d.
13 | P a g e
Na+ rushing out of the cell
K+ rushing out of the cellp. 22
30. A nurse is teaching the staff about platelet-derived growth factor. Which
information should the nurse include? Platelet-derived growth factor (PDGF)stimulates
the production of:
a.
b.
c.
d.
Platelets
Epidermal cells
Connective tissue cells
Fibroblast cells
ANS: C
Different types of cells require different growth factors; for example, PDGFstimulates
the production of connective tissue cells.
The factor stimulates the production of connective tissue, not platelets.
The factor stimulates the production of connective tissue, not epidermal cells.The factor
stimulates the production of connective tissue, not fibroblast cells.
REF: p. 24
31. The phase of the cell cycle during which the centromeres split and the sister
chromatids are pulled apart is referred to as:
a.
b.
c.
ANS: A
Anaphase begins when the centromeres split and the sister chromatids are pulledapart.
During telophase, the final stage, a new nuclear membrane is formed around each group of 46
chromosomes, the spindle fibers disappear, and the chromosomes begin touncoil.
During prophase, the first appearance of chromosomes occurs.
Metaphase occurs when two centrioles located at opposite poles of the cell pull the
chromosomes to opposite sides of the cell.
REF: p. 23
32. What is the role of cytokines in cell reproduction?
a.
Anaphase
Telophase
Prophase
d.
Metaphase
Provide growth factor for tissue growth and development
b.
c.
d.
Block progress of cell reproduction through the cell cycle
Restrain cell growth and development
Provide nutrients for cell growth and development
ANS: A
Cytokines play a major role in the regulation of tissue growth and development. Cytokines help
overcome intracellular braking mechanisms that restrain cell growth.Cytokines promote cell
14 | P a g egrowth, not restrain it.
Cytokines regulate growth; they do not provide nutrients.REF: p.
23
33. A biopsy of the lung bronchi revealed ciliated epithelial cells that are capable of
secretion and absorption. These cells are called
columnar epithelium.
a.
b.
Simple
Ciliated simple
15 | P a g ec.
d.
Stratified
Pseudostratified ciliated
ANS: B
Ciliated simple columnar epithelium are found in the lungs.
Simple columnar epithelium are found from the stomach to the anus.
Stratified columnar epithelium are found in the linings of epiglottis, part of pharynx,anus, and
male urethra.
Pseudostratified ciliate columnar epithelium is found in the linings of large ducts ofsome
glands (parotid, salivary), male urethra, respiratory passages, and eustachian tubes of ears.
REF: p. 26
34. The nurse would be correct in identifying the predominant extracellular cation as:
a.
Sodium
b.
c.
d.
Potassium
Chloride
Glucose
ANS: A
The predominant extracellular cation is sodium.
Potassium is the predominant intracellular cation.
Chloride is an anion. Urea is a nonelectrolyte.
Glucose is a nonelectrolyte.
REF: p. 20
35. The student is reviewing functions of the cell. The student would be correct in
identifying the primary function of the nerve cell as:
a.
b.
c.
d.
Sensory interpretation
Conductivity
Maintenance of homeostasis
Communication
ANS: B
Conduction as a response to a stimulus is manifested by a wave of excitation; an electrical
potential that passes along the surface of the cell to reach its other parts.Conductivity is the
chief function of nerve cells.
Nerve cells assist with sensory interpretation, but their primary function is
conductivity.
Nerve cells assist with maintenance of homeostasis, but their primary function is
conductivity.
Nerve cells assist with communication, but their primary function is conductivity.REF: p. 2
36. The student is studying for a pathophysiology exam and is trying to remember thedefinition
16 | P a g e
a.
All cells have a membrane that is composed of lipids.of amphipathic. The student should choose which of the following to be correct?
ANS: C
Amphipathic means that one part is hydrophobic (uncharged, or “water hating”) andanother
part is hydrophilic (charged, or “water loving”).
Cells have a membrane, but this is not the definition of amphipathic.Cells
have organelles, but this is not the definition of amphipathic.
Cells have receptor sites, but this is not the definition of amphipathic.REF: p. 3
MULTIPLE RESPONSE
1. A nurse recalls that the four basic types of tissues are (select all that apply):
a.
Nerve
b.
c.
d.
e.
f.
Epithelial
Mucosal
Connective
Skeletal
Muscle
ANS: A, B, D, F
Nerve is one of the four basic tissue types. Epithelial is
one of the four basic tissue types Connective is one of
the four basic tissue types.
Muscle is one of the basic tissue types.
Mucosal is a type of epithelial cell and is not a basic tissue type. Skeletal is a
type of connective tissue and is not a basic tissue type.REF: p. 24
2. Characteristics of prokaryotes include which of the following? (Select all thatapply.)
a.
b.
c.
They contain no organelles.
ANS: A, B
The prokaryotes contain no organelles.
The prokaryotic cells do not have their nuclear materials encased by a nuclear
membrane.
Prokaryotic cells are characterized by lack of a distinct nucleus.
Prokaryotes lack a class of proteins called histones, which in eukaryotic cells bindwith DNA
and are involved in the supercoiling of DNA.
Their nuclear material is not encased by a nuclear membrane.
They contain a distinct nucleus.
d.
e.
They contain histones.
They contain a cellular membrane.
17 | P a g eProkaryotic cells do not have a cellular membrane.REF: p.
2
Chapter 02: Genes and Genetic Diseases
Chapter 02: Genes and Genetic DiseasesTest Bank
MULTIPLE CHOICE
1. A nurse recalls the basic components of DNA are:
a.
Pentose sugars and four phosphate bases
b.
c.
d.
A phosphate molecule, deoxyribose, and four nitrogenous bases
Adenine, guanine, and purine
Codons, oxygen, and cytosine
ANS: B
DNA has three basic components: the pentose sugar molecule, deoxyribose; aphosphate
molecule; and four types of nitrogenous bases.
DNA contains four nitrogenous bases, not phosphate bases.
Adenine and quinine are purines and are only a portion of the components of DNA.DNA
synthesizes body protein, of which a codon is a component.
REF: p. 35
2. Which of the following mutations have the most significant effect on proteinsynthesis?
a.
b.
Base pair substitutions
Silent mutations
ANS: D
The frameshift mutation involves the insertion or deletion of one or more base pairs ofthe DNA
molecule. They alter the amino acid sequence.
The base pair substitution is a type of mutation in which one base pair replacesanother.
Silent mutations do not change amino acids or protein synthesis.Intron
mutations are part of RNA sequencing.
REF: p. 37
3. The base components of DNA are:
a.
c.
d.
Intron mutations
Frameshift mutations
A, G, C, and U
b.
c.
d.
P, G, C, and T
A, G, C, and T
X, XX, XY, and YY
ANS: C
The four base components of DNA are cytosine, thymine, adenine, and guanine andare
commonly represented by their first letters: A, C, T, and G.
18 | P a g eThe four base components of DNA are cytosine, thymine, adenine, and guanine andare
commonly represented by their first letters: A, C, T, and G. U is not included.
The four base components of DNA are cytosine, thymine, adenine, and guanine andare
commonly represented by their first letters: A, C, T, and G. P is not included.
X, XX, XY and YY are components of human chromosomes.
REF: p. 35
4. A DNA strand has a region with the sequence ATCGGAT. Which of the followingwould be a
complementary strand?
a.
b.
c.
CGATACGT
TAGCCTAG
TUGCCTUG
ANS: B
The consistent pairing of adenine with thymine and of guanine with cytosine is knownas
complementary base pairing; thus, A complements to T and C to G and vice versa throughout the
strand.
A complements to T; thus, the first letter must be a T.U does
not represent a complement in the sequence. U does not
represent a complement in the sequence. REF: p. 35
5. A biologist is explaining how RNA directs the synthesis of protein. Which processis the
biologist describing?
d.
UAGCCUAG
a.
b.
c.
d.
Termination
Transcription
Translocation
Translation
ANS: D
In translation, RNA directs the synthesis of a polypeptide, interacting with transferRNA
(tRNA), a cloverleaf-shaped strand of about 80 nucleotides.
At a termination signal, translation and polypeptide formation cease. This does notinvolve
synthesis of protein.
Transcription is the process by which DNA specifies a sequence of messenger RNA(mRNA).
Translocation is the interchange of genetic material between nonhomologous
chromosomes.
REF: p. 39
6. When homologous chromosomes fail to separate during meiosis, which of thefollowing
occurs?
19 | P a g ea.
b.
c.
d.
Neurofibromatosis
Nondisjunction
Polyploidy
Conjoined twins
ANS: B
Nondisjunction is an error in which homologous chromosomes or sister chromatidsfail to
separate normally during meiosis or mitosis.
Neurofibromatosis is a dominant disorder. It is not due to chromosome failure duringmeiosis.
Polyploidy occurs when a euploid cell has more than the diploid number of
chromosomes.
Conjoined twins are not due to chromosome failure during meiosis.REF: p.
42
7. A cell that does not contain a multiple of 23 chromosomes is called a
cell.
a.
b.
c.
d.
diploid
euploid
polyploid
haploid
ANS: C
A polyploid cell is one in which a euploid cell has more than the diploid number of
chromosomes.
A diploid cell is when the somatic cell nucleus has 46 chromosomes in 23 pairs.A euploid
cell is a cell with multiples of the normal number of chromosomes.
A haploid cell has only one member of each chromosome pair, for a total of 23
chromosomes.
REF: p. 39
8. A 20-year-old pregnant female gives birth to a stillborn child. Autopsy reveals thatthe fetus
has 92 chromosomes. What term may be on the autopsy report to describe this condition?
a.
b.
c.
Biploidy
Triploidy
Tetraploidy
20 | P a g ed.
Aneuploidy
ANS: C
Tetraploidy is a condition in which euploid cells have 92 chromosomes.Biploidy
is a euploid cell with 2 times more chromosomes, or 46.
Triploidy is a zygote that has three copies of each chromosome, rather than the usualtwo.
Aneuploidy is when an aneuploid cell does not contain a multiple of 23 chromosomes.REF: p. 40
9. The condition in which an extra portion of a chromosome is present in each cell iscalled:
a.
b.
Reciprocal translocation
Partial trisomy
ANS: B
Partial trisomy is a condition in which only an extra portion of a chromosome ispresent in
each cell.
A reciprocal translocation occurs when breaks take place in two different
chromosomes and the material is exchanged.
An inversion occurs when two breaks take place on a chromosome, followed by thereinsertion
of the missing fragment at its original site, but in inverted order.
Down syndrome is an aneuploidy of the twenty-first chromosome.REF: p.
40
10. After a geneticist talks to the patient about being a chromosomal mosaic, the patient
asks the nurse what that means. How should the nurse respond? You may
genetic disease(s).
c.
d.
Inversion
Down syndrome
a.
b.
c.
d.
Only be a carrier of the
Have a mild form of the
Have two
Be sterile as a result of the
ANS: B
A chromosomal mosaic means the body has two or more different cell lines, each ofwhich has a
different karyotype; thus, the person has a mild form of the disease.
Mosaics are not only carriers; they have the disease.
Mosaics have two different lines but not two different diseases.Mosaics
are not sterile.
REF: p. 42
11. The nurse is teaching staff about the most common cause of Down syndrome.What is
the nurse describing?
a.
b.
21 | P a g e
c.
d.
Paternal nondisjunction
Maternal translocations
Maternal nondisjunction
Paternal translocationsANS: C The most common cause of Down syndrome is maternal nondisjunction.Down syndrome is not related to paternal nondisjunction. Down syndrome is related to the maternal side, but not due to translocation.Down syndrome is not related to paternal abnormalities. REF: p. 42 12. A patient wants to know the risk factors for Down syndrome. What is the nurse’sbest response?
a. b. c. d.
Fetal exposure to mutagens in the uterus Increased paternal age
Family history of Down syndrome Pregnancy in women over age 35
ANS: D The primary risk for Down syndrome is pregnancy in women over 35.Down syndrome is a trisomy and not due to fetal exposure. Paternal age is not a risk factor in Down syndrome. Down syndrome is a chromosomal abnormality and is not related to family history.REF: p. 42 13. A 13-year-old girl has a karyotype that reveals an absent homologous X chromosome with only a single X chromosome present. What medical diagnosis willthe nurse observe on the chart? [Show Less]