Pathophysiology Final Exam Study Guide
• ATP function in cell metabolism
o ATP = ENERGY currency for the cell
• Aerobic and Anaerobic metabolism
o
... [Show More] Aerobic = requires oxygen to form CO2 and H2O as energy- Krebs cycle
o Anaerobic = no oxygen required; occurs in glycolysis = glucose → pyruvic acid
▪ lactic acid: what pyruvate turns during glycolysis when oxygen is not present
• Cell signaling and communication mechanisms
o Cell surface receptors:
▪ G protein linked receptors: Function as an on/ off switch to convert external signals (first
messengers- proteins, small peptides, amino acids, fatty acids) into internal signals (second
messengers- by the response of secretion, muscle contraction or relaxation or change in
metabolism).
▪ Enzyme linked receptors: Widely used in hormone control of cell function
▪ Ion channel linked receptors: Involved in rapid synaptic signaling between electrically excitable
cells in nerve and muscle cells.
• Membrane potentials and their functions
o Movement of ions in water.
o Changes in membrane potentials are necessary for generation and conduction of nerve impulses and
muscle contraction.
• Normal adaptive process (cell structure and function)
o Allows stressed tissue to the survived or maintain function.
• Atrophy: Decrease in cell size
• Hypertrophy: Increase in cell size
• Hyperplasia: Increase in number of cells
• Metaplasia: When one adult cell type is replaced by another adult cell type.
• Dysplasia: Deranged cell growth of a specific tissue.
• Two patterns of reversible cell injury
o cellular swelling: occurs with the impairment of energy- dependent
sodium potassium pump, as a result of a hypoxic cell injury.
o fatty changes: due to intracellular accumulation of fat, indicates cell
injury.
• Cell injury
o Hypoxic cell injury: Hypoxia deprives the cell of oxygen and
interrupts oxidative metabolism and the generation of ATP. The cell
swells with water
o Nutritional imbalances contribute to cell injury
• Apoptosis: Programmed cell death/ suicide. Removes worn out cells and
unwanted tissue.
• Necrosis: unregulated cell death caused by injuries to cells. Cell death and
degradation of cells that are part of living tissue. Cells swell and rupture which
results in inflammation. They are then destroyed by WBCs.
• Dry gangrene: lack of arterial blood supply but venous flow can carry fluid
out of tissue, tissue tends to coagulate.
• Wet gangrene: Lack of venous flow lets fluid accumulate in tissue, tissue tends to liquefy, and infection is likely.
• Gas gangrene: clostridium i [Show Less]