Sophia Smith - 14 Gene
ExpressionTranscription-S.pdf
Why?
Gene
Expression—
Transcription
How is mRNA synthesized and what message does it
... [Show More] carry?
DNA is often referred to as a genetic blueprint. In the same way that blueprints contain the instructions
for construction of a building, the DNA found inside the nuclei of cells contains the instructions for
assembling a living organism. The DNA blueprint carries its instructions in the form of genes. In most
cases the genes direct the production of a polypeptide, from which other more complex proteins, such as
enzymes or hormones, may be constructed. These polypeptides and other molecules run the organism’s
metabolism and, in multicellular organisms, dictate what each cell’s job is. So, what is the language of
these instructions and how are they read and decoded by the cellular organelles? This activity will focus on
the decoding of genes in eukaryotes
Model 1 – Transcription
5´ 3´
Chromosome from a
nondividing cell
Inside the Nucleus
Template (reading) strand
A
C
A U
RNA polymerase and
Outside the Nucleus
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2 POGIL Activities for AP* Biology
1. Consider the eukaryotic cell in Model 1.
a. Where in the cell is the DNA found?
b. Where in the cell does transcription take place?
2. Refer to Model 1.
a. What polymer is synthesized during transcription?
b. What monomers are used to construct this polymer and where are they found?
3. According to Model 1, what enzyme is required for transcription? (Hint: Think about how
enzymes are named. What ending is used for enzyme names?)
4. Refer to Model 1.
a. What isthe base-pair rule for a DNA strand matching an RNA strand?
b. Compare this base-pair rule with that of two DNA strands.
5. Which strand of the DNA contains the “blueprint” for the pre-mRNA?
6. Consider Model 1.
a. In which direction is the DNA molecule read?
b. The DNA strand and pre-mRNA strand are anti-parallel. With this in mind label the 3ʹ and
5ʹ ends of the pre-mRNA strand in Model 1.
c. In which direction is the pre-mRNA molecule constructed?
7. Before printing presses were available, books had to be transcribed in order to share the information in them. Consider the definition of transcription and explain why the process in Model 1 is
described using that word.
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