Rush University - NSG 533 Module 10 Shock Sepsis MODS Objectives Study Guide. Latest 2021.Define the terms infection, bacteremia, systemic inflammatory
... [Show More] response syndrome (SIRS), sepsis, septic
shock, and multiple organ dysfunction syndrome (MODS)
o Infection: invasion of normally sterile tissue/organism with some infectious organism(s)
o Bacteremia: presence of viable infectious bacteria in the blood
o Systemic Inflammatory Response Syndrome (SIRS): non specific systemic inflammation; may or
may not be infectious
o Shock: cellular/tissue hypoxia due to either decreased 02 deliver, increased 02 consumptions
and/or inadequate 02 utilization
What is shock? The inability of the body to maintain adequate cell & tissue perfusion
Shock results in the inability to maintain VS, oxygenation, glucose delivery/use,
removal waste product
o Sepsis: Life threatening organ dysfunction caused by dysregulated host response to an
overwhelming infection
o Septic Shock: subset of sepsis with circulatory and cellular/metabolic dysfunction requiring
intervention and associated with higher risk of mortality than sepsis alone
o Multi Organ Dysfunction Syndrome (MODS): progressive organ dysfunction, normal homeostasis
cannot be maintained without intervention(s)
Compare and contrast etiology, risk factors and pathophysiology of cardiogenic, hypovolemic, anaphylactic,
neurogenic, and septic shock states
o All shock states have this in common:
Inadequate tissue perfusion impaired cellular metabolism
Decreased oxygenation – decreased delivery and/or increased demand
Decreased delivery of nutrients – decreased delivery and/or increased demand
Decreased removal of cellular waste products
o Cardiogenic Shock
Cardiogenic shock results from the inability of the heart to pump adequate blood to tissues
and end organs from any cause, most common being the short-term consequences of an
acute MI or a severe episode of myocardial ischemia
Cardiogenic shock is defined as persistent hypotension and tissue hypoperfusion caused by
cardiac dysfunction in the presence of adequate intravascular volume and left ventricular
filling pressure
Pathologic conditions that reduce contractility, cause pump failure, impair diastolic filling, or
cause obstruction can lead to cardiogenic shock:
Decreased contractility/pump failure:
o Acute MI, cardiomyopathy, sepsis, myocarditis, pericarditis, aneurysm,
dysrhythmias, contusion, metabolic abnormalities, papillary muscle rupture
Impaired diastolic filling:
o Related to dysthymias
Obstruction:
o Attributable to pulmonary embolism, cardiac tamponade, valvular disorders,
tumors, and wall rupture/defect [Show Less]