HS 200 - Unit 8 Quiz Question 1 2 / 2 points Which of the following is NOT true of Down syndrome? Question options: 1) It is a chromosomal disorder in
... [Show More] which cells have three copies of chromosome 21. 2) All affected individuals experience cognitive delays, but the intellectual disability is usually mild to moderate. 3) In most cases, it is inherited. 4) The abnormality usually occurs in egg cells, but it occasionally occurs in sperm cells. Question 2 2 / 2 points The Human Genome Project has estimated that humans have between _______ and _____ genes. Question options: 1) 10,000, 15,000 2) 5,000, 7,000 3) 50,000, 70,000 4) 20,000, 25,000 Question 3 0 / 2 points Cystic fibrosis gene has been located on: Question options: 1) chromosome 7 2) chromosome 10 3) chromosome 9 4) chromosome 15 Question 4 0 / 2 points Which of the following statements is NOT true about hereditary mutations? Question options: 1) They are present only in a few cells in a body. 2) They are present in virtually every cell in the body. 3) They are present throughout a person’s life. 4) They are inherited from a parent. Question 5 2 / 2 points Klinefelter syndrome: Question options: 1) occurs in males, with an extra chromosome 21. 2) occurs in females with 1 extra X chromosome. 3) is characterized by short stature and a broad neck. 4) is a chromosomal condition that occurs in boys and men, that can affect physical and intellectual abilities. Question 6 2 / 2 points In Klinefelter syndrome, there is an addition of an extra X chromosome, which: Question options: 1) is present in all the cells in one of the parents. 2) occurs only in females. 3) occurs during the formation of reproductive cells (egg or sperm) in one of an affected person’s parents. 4) is inherited. Question 7 2 / 2 points In normal development, how many pairs of chromosomes do people have in each cell? Question options: 1) 2 pairs 2) 22 pairs 3) 23 pairs 4) 46 pairs Question 8 2 / 2 points Genes are defined as: Question options: 1) the basic unit of heredity 2) specific sequences of RNA 3) Entities, which vary in size, maximum length being less than 100 DNA bases, in humans 4) abnormalities of chromosome structure Question 9 2 / 2 points A gene mutation is when there is: Question options: 1) a temporary alteration in a sequence of DNA 2) a temporary alteration in a sequence of RNA 3) a permanent l alteration in a sequence of RNA 4) a permanent alteration in a sequence of DNA Question 10 2 / 2 points Which of the following statements is NOT true about Turner syndrome? Question options: 1) Most cases of Turner syndrome are not inherited. 2) the chromosomal abnormality occurs as a random event during the formation of reproductive cells (eggs and spe the affected person's parents. 3) A child with Turner syndrome will have a single X chromosome in each cell and will be missing the other sex chromosome. 4) Most cases of Turner syndrome are inherited. Question 11 2 / 2 points Early-onset Alzheimer’s disease is inherited in: Question options: 1) An autosomal dominant pattern. 2) An autosomal recessive pattern. 3) An X-linked recessive pattern. 4) An X-linked dominant pattern. Question 12 2 / 2 points Alzheimer’s disease is a degenerative disease of the brain that causes dementia. Which of the following statements is NOT true about Alzheimer’s disease? Question options: 1) This disorder is more common in people older than age 65. 2) Some of early-onset Alzheimer’s disease are caused by gene mutations that can be passed from parent to child. 3) When certain genes are altered, large amounts of a toxic protein called amyloid beta peptide are produced in the b This process can lead to the formation of clumps called amyloid plaques. 4) Late-onset Alzheimer’s disease is inherited in an autosomal dominant pattern. Question 13 2 / 2 points Which of the following is an example of an autosomal dominant disease? Question options: 1) Huntington disease 2) Cystic fibrosis 3) Sickle cell anemia 4) Down syndrome Question 14 2 / 2 points Acquired (or somatic) mutations: Question options: 1) Can be passed to the next generation. 2) Are present in every cell in the body. 3) Are present only in certain cells. 4) Are not caused by ultraviolet radiation. Question 15 0 / 2 points Which is NOT true about de novo (new) mutations: Question options: 1) In some cases, the mutations occur in egg cell only. 2) In some cases, the mutations occur in fertilized egg shortly after the egg and sperm cells unite. 3) De novo mutations can be either hereditary or somatic. 4) After de novo mutations, as the fertilized cell divides each resulting cell in the growing embryo will have the mutations. Question 16 2 / 2 points Most genetic disease-causing gene mutations are uncommon in the general population. However, some genetic changes occur more frequently. Genetic alterations that occur in more than ______ percent of the population are called polymorphisms. Question options: 1) 0.05 2) 0.1 3) 1.0 4) 0.15 Question 17 2 / 2 points Sickle-cell disease: Question options: 1) Is caused by mutation in the hemoglobin gene, HBB. 2) Is inherited in an X-linked recessive pattern. 3) Occurs when an individual carry one copy of the mutated gene. 4) Is caused by mutation in the gene for an enzyme in the blood clotting cascade. Question 18 2 / 2 points Hemophilia is a bleeding disorder: Question options: 1) that can be of two major types, Hemophilia A and B and they are caused by mutations in the same gene. 2) that is inherited in an autosomal dominant pattern. 3) that slows the blood clotting process. 4) that results in damages to the lungs. Question 19 2 / 2 points Which of the following is true of phenylketonuria (PKU)? Question options: 1) PKU is inherited by an autosomal dominant pattern. 2) It is caused by an excess of the enzyme phenylalanine hydroxylase. 3) PKU does not affect a child’s intellectual ability in later life. 4) Phenylketonuria is caused by the mutation in the gene for the enzyme Phenylalanine hydroxylase. Question 20 0 / 2 points Cystic fibrosis: Question options: 1) Is inherited in an autosomal recessive pattern. 2) Is a genetic disease in which one of the two copies of the gene in each cell, has a mutation. 3) Is a genetic disease in which mutations in the CFTR gene disrupt the functions of the calcium channels. 4) Is not inherited. Question 21 2 / 2 points Phenylketonuria (PKU) is an inherited disorder that increases the levels of phenylalanine in blood. Without treatment, children with classic Phenylketonuria (PKU) develop all of the following except: Question options: 1) permanent intellectual disability 2) behavioral problem 3) odor 4) liver disease Question 22 2 / 2 points Genetic testing can provide information about a person's genes and chromosomes. Available types of testing include: Question options: 1) Prenatal testing, diagnostic testing, and carrier testing 2) Ultrasound 3) Magnetic resonance imaging 4) X-ray Question 23 2 / 2 points Predictive and presymptomatic types of testing are used to detect: Question options: 1) Gene mutations associated with disorders that appear after birth, often later in life. 2) Chromosomal abnormalities in fetus. 3) Gene mutations during pregnancy. 4) Gene mutations in fetus. Question 24 2 / 2 points Prenatal testing: Question options: 1) Is used to detect changes in a fetus’s genes or chromosomes before birth. 2) Can identify all possible inherited disorders. 3) Can identify all possible birth defects. 4) Is compulsory. Question 25 2 / 2 points Screening tests: Question options: 1) Are done to see if a woman or her baby might have certain problems. 2) Provide diagnosis. 3) Never result in information. 4) Never miss a problem that does exist. Question 26 2 / 2 points In the first trimester, an ultrasound: Question options: 1) Can detect chromosomal disorder and heart defect in the baby. 2) Can detect genetic mutation in the baby. 3) Cannot create pictures of the baby. 4) cannot detect extra fluid behind the baby’s neck. Question 27 2 / 2 points Diagnostic tests are offered: Question options: 1) If the result of a screening test is abnormal. 2) To all pregnant women. 3) Even the pregnant woman has no risk 4) Only to women who are 35 years of age or older. Question 28 2 / 2 points In the first trimester, maternal blood screen is completed which is a blood test that measures the levels: Question options: 1) Human chorionic gonadotropin (hCG) and pregnancy associated plasma proteins (PAPP-A). 2) Inhibin-A and alpha-fetoprotein. 3) Estriol and testosterone. 4) Estriol and progesterone. Question 29 2 / 2 points Some of the reasons for genetic testing are all of the following except: Question options: 1) To learn whether one has a genetic condition that runs in his/her family. 2) To learn about the chance a current or future pregnancy will have a genetic condition. 3) To understand about cancer prevention and treatment plans. 4) Genetic tests are inexpensive. Question 30 0 / 2 points The triple screen test is used to determine: Question options: 1) neural tube defects 2) cardiovascular disease 3) immunologic diseases 4) all genetic conditions Question 31 2 / 2 points The quad test, which is performed on the serum of pregnant women, measures which substance? Question options: 1) inhibin-A 2) syphilis antibodies 3) iron levels 4) hemoglobin Question 32 2 / 2 points Chorionic Villus Sampling (CVS) is a test where the doctor collects a tiny piece of placenta, known as chorionic villus and tests to check for chromosomal or genetic disorder in a baby. This procedure is completed between: Question options: 1) 18–20 weeks of pregnancy. 2) 6–9 weeks of pregnancy. 3) 24–30 weeks of pregnancy. 4) 10–12 weeks of pregnancy. Question 33 2 / 2 points Amniocentesis is a test where the doctor collects a small amount of amniotic fluid from the area surrounding the baby. Cells in the amniotic fluid can be tested for: Question options: 1) Autism 2) Birth defects such as neural tube defect, genetic problems such as Cystic fibrosis or Tay Sachs disease, and chromosomal disorders such as Down syndrome. 3) Neural tube defect only. 4) Genetic defects only. Question 34 2 / 2 points Newborn screening that is mandatory in all states includes: Question options: 1) Down syndrome testing 2) Fetal diseases testing 3) Phenylketonuria testing 4) Carrier testing Question 35 2 / 2 points Different types of genetic testing used to detect gene mutations associated with a disease include all of the following except: Question options: 1) predictive testing 2) carrier testing 3) forensic testing 4) newborn screening Question 36 2 / 2 points Some of the things genetic counselors can do include all of these except: Question options: 1) assess the risk of a genetic disorder. 2) offer detailed explanations of the specific genetic disorder, the tests that are available, and the inheritance pattern 3) treat genetic conditions. 4) work with the patient’s health care provider. Question 37 2 / 2 points Women/couples who are pregnant or planning to become pregnant may see a prenatal genetic counselor when: Question options: 1) They want information on normal development of infants. 2) They have normal ultrasound findings. 3) When there is a personal or family history of a known or suspected conditions. 4) They want to find the incidence rates of a disorder in a community. Question 38 0 / 2 points AFP stands for alpha-feto protein, a protein that unborn baby produces. A high level of AFP in amniotic fluid indicates: Question options: 1) That the baby might be overweight. 2) That the baby might have a genetic condition called Phenylketonuria. 3) That the baby is healthy. 4) That the baby might have a neural tube defect. Question 39 2 / 2 points In second trimester screening, maternal serum screen is used to identify if a woman is at increased risk of having a baby with birth defects such as: Question options: 1) Phenylketonuria (PKU). 2) Cystic fibrosis 3) Neural tube defects 4) Sickle cell anemia Question 40 2 / 2 points Second trimester screening tests include anomaly ultrasound that creates a picture of the baby in the womb. This test is usually completed around: Question options: 1) 18–20 weeks of pregnancy. 2) 8–12 weeks of pregnancy. C. 24–28 weeks of pregnancy. D. 30–34 weeks of pregnancy. Question 41 0 / 2 points Sex-linked genes are located on the: Question options: 1) X or Y chromosomes 2) autosomes 3) X chromosome only 4) Y chromosome only Question 42 2 / 2 points Common genetic variations that occur in more than 1 percent of the population are called: Question options: 1) alleles 2) polymorphisms 3) hereditary mutations 4) germline mutations Question 43 2 / 2 points Hemophilia is: Question options: 1) a bleeding disorder caused by a gene mutation. 2) caused by mutation in the hemoglobin gene, HBB. 3) a genetic disease in which mutations in the CFTR gene disrupt the functions of the calcium channels. 4) a genetic disorder that results in damage to the lungs. Question 44 2 / 2 points Which of the following is an example of an autosomal recessive disease? Question options: 1) Huntington disease 2) Cystic fibrosis 3) Klinefelter syndrome 4) Down syndrome Question 45 2 / 2 points Klinefelter syndrome: Question options: 1) is a chromosomal condition in which there is an extra X chromosome in all the cells. 2) occurs only in female. 3) is a genetic condition caused by single gene mutation. 4) is inherited. Question 46 2 / 2 points Sickle-cell anemia is primarily a condition of the: Question options: 1) red blood cells 2) pancreas 3) lungs 4) nervous system Question 47 2 / 2 points Cystic fibrosis is primarily a condition of the: Question options: 1) red blood cells 2) pancreas 3) lung and digestive system 4) nervous system Question 48 0 / 2 points In normal human, what are the total number of chromosomes in each cell? Question options: 1) 47 2) 46 3) 45 4) 23 Question 49 0 / 2 points Chromosomal diseases are often diagnosed by: Question options: 1) blood culture 2) ultrasound 3) physical examination 4) family history Question 50 0 / 2 points Tests for neural tube defects are most sensitively diagnosed by: Question options: 1) amniocentesis 2) triple screen 3) quad test 4) ultrasonography Attempt Score: 80 / 100 - 80 % Overall Grade (highest attempt): 80 / 100 - 80 % [Show Less]