What are the major functions of the α1 receptor? - ANSWER Increase vascular smooth muscle contraction, increase pupillary dilator muscle contraction
... [Show More] (mydriasis), increase intestinal and bladder sphincter muscle contraction
What are the major functions of the α2 receptor? - ANSWER Decrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease aqueous humor production
What are the major functions of the β1 receptor? - ANSWER Increase heart rate, increase contractility, increase renin release, increase lipolysis
What are the major functions of the β2 receptor? - ANSWER Vasodilation, bronchodilation, increase lipolysis, increase insulin release, decrease uterine tone (tocolysis), ciliary muscle relaxation, increase aqueous humor production
What are the major functions of the M1 receptor? - ANSWER CNS, enteric nervous system
What are the major functions of the M2 receptor? - ANSWER Decrease heart rate and contractility of atria
What are the major functions of the M3 receptor? - ANSWER Increase exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut peristalsis, increase bladder contraction, increase bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation)
What are the major functions of the D1 receptor? - ANSWER Relaxes renal vascular smooth muscle
What are the major functions of the D2 receptor? - ANSWER Modulates transmitter release, especially in the brain
What are the major functions of the H1 receptor? - ANSWER Increase nasal and bronchial mucus production, increase vascular permeability, contraction of bronchioles, pruritis, pain
What are the major functions of the H2 receptor? - ANSWER Increase gastric acid secretion
What are the major functions of the V1 receptor? - ANSWER Increase vascular smooth muscle contraction
What are the major functions of the V2 receptor? - ANSWER Increase H2O permeability and reabsorption in collecting tubules of kidney (V2 is found in the "2" kidneys)
What receptors are associate with Gq? - ANSWER H1, α1, V1, M1, and M3
What receptors are associated with Gs? - ANSWER H2, B1, B2, V2, D1
What receptors are associated with Gi? - ANSWER M2, α2, D2
Bethanechol - ANSWER -Direct cholinergic agonist
-Activates bowel and bladder smooth muscle
-Used in postoperative and neurogenic ileus
-Resistant to AChE [Show Less]