PACOP VIOLET MODULE 4. BIOPHARMACEUTICS AND PHARMACOKINETICS.1. It is the ability of a drug to exist in two or more
crystalline form:
A. Chirality
B.
... [Show More] Polymorphism
C. Stereoisomerism
D. A and C
E. None of these
2. Arrange the following dosage forms from
highest to lowest dissolution rate:
I. Solution
II. Capsule
III. Suspension
IV. Tablet
A. I, II, III, IV
B. I, III, II, IV
C. IV, III, II, I
D. IV, II, III, I
E. None of these
3. All of the following statements are true
regarding particle size of a drug, EXCEPT:
A. Reducing the particle size can decrease the
surface are of the molecule exposed to the
solvent
B. Reduction of particle size can be achieved by
micronisation using jet mill, spray drying and air
attrition methods
C. The dissolution of some drugs available in the
market has been improved by reducing the
particle size
D. Reducing the particle size of a drug may
increase drug absorption
E. None of these
4. Which of the following may increase drug
dissolution rate?
I. Too much binder
II. Insoluble diluents
III. High amount of lubricants
A. I only
B. I and II
C. II and III
D. I, II and III
E. None of these
5. Which of the following is not true regarding
the purpose of tablet coating?
A. Improves palatability
B. Improve aesthetic value of tablet
C. Improve stability
D. Improve in-vivo degradation
E. None of these
6. A surface active agent that facilitates the
absorption of lipophilic drug or water insoluble
drugs.
A. Bile
B. Albumin
C. Rennin
D. Gastric acid
E. None of these
7. Phase 2 metabolism that protects the body
against chemically reactive metabolites
A. Sulfate conjugation
B. Glutathione conjugation
C. Methylation
D. Acetylation
E. Glycine conjugation
8. All of the following listed below are
procecesses of drug excretion, EXCEPT
A. Glomerular filtration
B. Active secretion
C. Tubular secretion
D. Tubular reabsorption
E. None of these
9. It is the functional unit of the kidney
A. Glomerulus
B. Loop of henle
C. Nephron
D. Collecting tubule
E. None of these
10. Creatinine clearance of a patient with kidney
failure
A.60-89 mL
B. 30-59 mL
C.15-29 mL
D. <15 mL
E. None of these
11. Which of the following drugs listed below will
increase its clearance at alkaline urine?
I. Amphetamine
II. Imipramine
III. Barbiturates
IV. Salicylic acid
A. I and II
B. II and III
C. III and IV
D. All of these
E. None of these
12. Which of the following correctly describes
ion trapping?
A. Changing the pH of urine used to facilitate the
elimination of drug that proved to be toxic to a
patient or has been taken in overdosed amount
B. Administration of acidic drug to neutralize an
alkaline poison in the stomach
C. Alkalanizing the urine to facilitate excretion of
weakly basic drugs
D. A and C
E. None of these
13. Discipline that applies pharmacokinetic
concepts and principles in humans in order to
design individualized dosage, regimens that
optimize the therapeutic response of a
medication while minimizing the chance of an
adverse drug reaction.
A. Clinical toxicology
B. Clinical pharmacy
C. Clinical pharmacokinetics
D. Pharmacotherapeutics
E. None of these
14. Chemical coversion of the drug molecule,
usually by an enzymatically mediated reaction,
into another chemical entity referred to as a
metabolite.
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
E. None of these
15. Volume of serum or blood completely
cleared of the drug per unit time.
A. Volume of distribution
B. Clearance
C. Elimination
D. Plasma concentration
E. None of these
16. Hypothetical volume that relates drug serum
concentrations to the amount of drug in the
body.
A. Volume of distribution
B. Clearance
C. Drug elimination
D. Plasma concentration
E. None of these
17. All of the following factors affects the volume
of distribution of drug, EXCEPT:
A. Volume of blood
B. Size of venous organs and tissues in the
body
C. Protein binding
D. Physicochemical properties of drug
E. None of these [Show Less]