NURS 406 Pharmacology Nursing
What are the major functions of the α1 receptor? - CORRECT ANSWER--Increase vascular smooth muscle contraction,
... [Show More] increase pupillary dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter muscle contraction
What are the major functions of the α2 receptor? - CORRECT ANSWER--Decrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease aqueous humor production
What are the major functions of the β1 receptor? - CORRECT ANSWER--Increase heart rate, increase contractility, increase renin release, increase lipolysis
What are the major functions of the β2 receptor? - CORRECT ANSWER--Vasodilation, bronchodilation, increase lipolysis, increase insulin release, decrease uterine tone (tocolysis), ciliary muscle relaxation, increase aqueous humor production
What are the major functions of the M1 receptor? - CORRECT ANSWER--CNS, enteric nervous system
What are the major functions of the M2 receptor? - CORRECT ANSWER--Decrease heart rate and contractility of atria
What are the major functions of the M3 receptor? - CORRECT ANSWER--Increase exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut peristalsis, increase bladder contraction, increase bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation)
What are the major functions of the D1 receptor? - CORRECT ANSWER--Relaxes renal vascular smooth muscle
What are the major functions of the D2 receptor? - CORRECT ANSWER--Modulates transmitter release, especially in the brain
What are the major functions of the H1 receptor? - CORRECT ANSWER--Increase nasal and bronchial mucus production, increase vascular permeability, contraction of bronchioles, pruritis, pain
What are the major functions of the H2 receptor? - CORRECT ANSWER--Increase gastric acid secretion
What are the major functions of the V1 receptor? - CORRECT ANSWER--Increase vascular smooth muscle contraction
What are the major functions of the V2 receptor? - CORRECT ANSWER--Increase H2O permeability and reabsorption in collecting tubules of kidney (V2 is found in the "2" kidneys)
What receptors are associate with Gq? - CORRECT ANSWER--H1, α1, V1, M1, and M3
What receptors are associated with Gs? - CORRECT ANSWER--H2, B1, B2, V2, D1
What receptors are associated with Gi? - CORRECT ANSWER--M2, α2, D2
Bethanechol - CORRECT ANSWER---Direct cholinergic agonist
-Activates bowel and bladder smooth muscle
-Used in postoperative and neurogenic ileus
-Resistant to AChE
Carbachol - CORRECT ANSWER---Direct cholinergic agonist
-Carbon copy of acetylcholine
-Constricts pupils and relieves intraocular pressure in glaucoma
Methacholine - CORRECT ANSWER---Direct cholinergic agonist
-Stimulates muscarinic receptors in airways when inhaled
-Used as a challenge test for diagnosis of asthma
Pilocarpine - CORRECT ANSWER---Direct cholinergic agonist
-Contracts ciliary muscle of eye (open angle glaucoma), contracts pupillary sphincter (closed angle glaucoma)
-Potent stimulator of sweat, tears and saliva
-AChE resistant
Donepezil - CORRECT ANSWER---Anticholinesterse - increases ACh
-Alzheimer disease
Galantamine - CORRECT ANSWER---Anticholinesterse - increases ACh
-Alzheimer disease
Rivastigmine - CORRECT ANSWER---Anticholinesterse - increases ACh
-Alzheimer disease
Edrophonium - CORRECT ANSWER---Anticholinesterse - increases ACh
-Historically used to diagnose myasthenia gravis (MG is now diagnosed by anti-AChR Ab test.
Neostigmine - CORRECT ANSWER---Anticholinesterse - increases ACh
-Used in postoperative and neurogenic ileus and urinary retention, myasthenia gravis, and postoperative reversal of neuromuscular junction blockade [Show Less]