NURS 3460 Antilipemic and Hematology Medication Table - 2021
Antilipemic and Hematology Medication Table
This table will make you able to “Go
... [Show More] with your GUT ASAP!”
Group / Class
(Prototype) Use Therapeutic
Effects Adverse Effects Safety Concerns Administrati
on Patient Education
HMG-Coa
Reductase Inhibitors:
- Simvastati n (Simvastati n and ezetimibe combinatio n)
- Atorvastati n
- Lovastatin One of the most widely used drugs in the U.S.; most powerful for reducing LDL
Decrease LDL, VLDL, &
triglycerides; increase HDL; other benefits
Primary hypercholestere mia, prevention of coronary events, MI protection for DM One of the most widely used drugs in the U.S.; most powerful for reducing LDL
Decrease LDL, VLDL, &
triglycerides; increase HDL; other benefits
Primary hypercholestere mia, prevention of coronary events, MI protection for DM • Hepatotoxicit y: baseline and monitor AST; report symptoms; avoid alcohol
• Myopathy (muscle aches, tenderness): can lead to myositis or rhabdomyolys is; risk for older/frail clients; baseline and monitor CK; report symptoms • Contraindicated for pregnancy, lactation, liver disorder
– Contraceptive s
– Caution for previous liver disease
– Dose reduction for severe kidney impairment
Interactions:
• Fibrates & ezetimibe increase risk for myopathy/kidney injury
• CYP3A4 medications, HIV protease inhibitors, amiodarone, cyclosporine: increase statin levels
• Grapefruit juice: increase statin levels
Lovastatin with evening meal, others without regard to food but at night Orally • Report symptoms of hepatotoxicity (jaundice, anorexia, N/V)
• Avoid alcohol
• Report muscle pain
• Use contraception
• Discuss other medications
• Avoid grapefruit
Keep up with lab work
Cholesterol Blocks dietary • Blocks • Hepatitis: • Contraindicated for Orally • Observe for
Absorption Inhibitors:
- Ezetimibe cholesterol absorption in intestines and bile cholesterol reabsorption
Often combined with statin dietary cholester ol absorptio n in intestine s and bile cholester ol reabsorp tion
• Often combine d with statin baseline & monitor, report symptoms, avoid alcohol
• Myopathy: baseline & monitor; report symptoms moderate to severe hepatic impairment
• Caution for pregnancy, lactation and mild hepatic impairment
Interactions:
- Bile acid sequestrants interfere w absorption; separate administration
- Statins: increase risk for liver dysfunction & myopathy
- Fibrates: increase risk of cholelithiasis & myopathy; avoid
- Cyclosporine: increases ezetimibe levels and report symptoms of liver dysfunction & myopathy
• Use contraception
• Keep up with lab work
• Low-fat, low- cholesterol diet
• Regular exercise [Show Less]