1. Question :
The major impact of the physiological changes that occur with aging is:
Reduced physiological reserve
Reduced homeostatic
... [Show More] mechanisms
Impaired immunological response
CORRECT All of the above
Instructor Explanation: The major impact of all of these physiological changes can be
highlighted with three primary points. First, there is a reduced physiological reserve of most body
systems, particularly cardiac, respiratory, and renal. Second, there are reduced homeostatic mechanisms
that fail to adjust regulatory systems such as temperature control and fluid and electrolyte balance.
Third, there is impaired immunological function: infection risk is greater, and autoimmune diseases are
more prevalent. (Kennedy-Malone 3)
Kennedy-Malone, Laurie, Kathleen Fletcher, Lori Martin-Plank. Advanced Practice Nursing in the Care of
Older Adults. F.A. Davis Company, 2014-01-14. VitalBook file.
Question 2. Question :
Men have faster and more efficient biotransformation of drugs and this is thought to be due to:
Less obesity rates than women
Prostate enlargement
CORRECT Less estrogen than women
Instructor Explanation: Men have faster and more efficient biotransformation, presumably
because ofserum testosterone. Conditions of increased or decreased liver perfusion alter the overall
level of the drug that is absorbed and how it is metabolized. (Kennedy-Malone 5)
Kennedy-Malone, Laurie, Kathleen Fletcher, Lori Martin-Plank. Advanced Practice Nursing in the Care of
Older Adults. F.A. Davis Company, 2014-01-14. VitalBook file.
Question 3. Question :
The cytochrome p system involves enzymes that are generally:
Inhibited by drugs
South University 2
NSG6420
Induced by drugs
CORRECT Inhibited or induced by drugs
Associated with decreased liver perfusion
Instructor Explanation: Biotransformation occurs in all body tissues but primarily in the liver,
where enzymatic activity (cytochrome P [CYP]system) alters and detoxifies the drug and prepares it for
excretion. (Kennedy-Malone 5)
Kennedy-Malone, Laurie, Kathleen Fletcher, Lori Martin-Plank. Advanced Practice Nursing in the Care of
Older Adults. F.A. Davis Company, 2014-01-14. VitalBook file.
Question 4. Question :
Functional abilities are best assessed by:
Self-report of function
CORRECT Observed assessment of function
A comprehensive head-to-toe exam [Show Less]