Which drug class is most effective in treating erosive lesions:? - ANS-PPIs
Name 4 H2RAs: - ANS-Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine
... [Show More] (Zantac)
Nizatidine (Axid)
What is the action of H2RAs? - ANS-Decrease acid secretion by blocking histamine 2-
receptors in gastric parietal cells
Name 4 benefits of H2RAs - ANS-1. Relieve GERD symptoms
2. Can be administered prophylactically
3. More effective at controlling chronic GERD symptoms than ANTACIDS
4. Intermittent & routine dosing possible based on degree of symptom control needed.
Name 2 drawbacks of H2RAs - ANS-1. Less effective in controlling chronic GERD
symptoms than PPIs
2. Renal elimination may require dose adjustment in kidney dysfunction patients
What are the side effects associated with H2RAs? - ANS-H/A, nausea (Cimetidine),
weak inhibitor, common drug interactions, gynecomastia, & Vit B-12 deficiency which
affects patients' tolerance
Name the benefits of Antacids - ANS-1. Useful for intermittent treatment of GERD
symptoms
2. Immediate symptom relief
3. Usually well-tolerated
What are the drawbacks of Antacids? - ANS-1. Requires frequent dosing
2. Aluminum or Magnesium containing antacids may result in electrolyte imbalances
esp. in pts. w/renal impairment
3. May interfere w/absorption of fluoroquinolones, tetracyclines, iron products, & thyroid
hormones
(doses should be several hours apart)
What are the side effects of Antacids? - ANS-May cause
Constipation or Diarrhea depending on the formulation used
What is the Pharmacological Therapy Effectiveness of Antacids? - ANS-Antacids briefly
neutralize gastric acid but lacks acid-suppressive properties & are inferior to H2RAsWhat is the Pharmacological Therapy Effectiveness of H2RAs? - ANS-Histamine-2
Receptor Antagonists decrease acid secretion to a lesser extent than PPIs (& are
therefore inferior to PPIs)
What is the Pharmacological Therapy Effectiveness of PPIs? - ANS-Proton Pump
Inhibitors block the rate-limiting step in acid secretion from gastric parietal cells & block
all pathways for gastric acid secretion & therefore are better than H2RAs [Show Less]