A patient is newly diagnosed with HIV and has a history of previously receiving cabotegravir for preexposure prophylaxis. Results from a standard genotype
... [Show More] resistance assay and integrase resistance genotype are pending.
Which one of initial antiretroviral regimen is indicated if starting therapy before the genotype results return? - Darunavir-cobicitat-tenofovir alafenamide-emtricitabine
Which one of the following antiretroviral medications binds to a human cell surface receptor? - Ibalizumab
According to the Adult and Adolescent ART Guidelines, at what CD4 threshold should antiretroviral therapy be recommended for persons with HIV? - Antiretroviral therapy is recommended for all, regardless of CD4 cell count
According to the Adult and Adolescent ART Guidelines, which one of the following is classified as a recommended initial regimen for most people with HIV (presume no history of receiving cabotegravir for preexposure prophylaxis)? - Dolutegravir plus tenofovir alafenamide-emtricitabine
A 28-year-old cisgender man is newly diagnosed with HIV and a baseline HIV RNA level of 96,560 copies/mL starts taking the antiretroviral therapy regimen bictegravir-tenofovir alafenamide-emtricitabine.
After starting the antiretroviral therapy, when should the HIV RNA level next be checked? - Within 4 to 8 weeks
Which one of the following antiretroviral therapy regimens has been most clearly associated with weight gain? - Dolutegravir plus tenofovir alafenamide-emtricitabine
Which one of the following medications requires baseline HLA-B*5701 testing to identify persons at increased risk of developing a medication-related hypersensitivity reaction? - Abacavir
Which organs are most likely to be adversely impacted by long-term tenofovir DF therapy? - Renal insufficiency and reduce bone mineral density
A 36-year-old cisgender woman with HIV starts on antiretroviral therapy with the single tablet regimen dolutegravir plus tenofovir alafenamide-emtricitabine. She tolerates the regimen well, but at a follow-up visit 6 weeks later, the baseline serum creatinine of 1.0 mg/dL has increased to 1.2 mg/dL. A urinalysis showed no proteinuria. Over the next 9 months, the serum creatinine remains stable at a level of 1.1 to 1.3 mg/dL.
What is the most likely explanation for this small, but persistent increase in serum creatinine? - Inhibition of tubular secretion of creatinine by dolutegravir [Show Less]