NR 566 Week 4 Study Outline .Latest 2020/21.NR566 Week 4 Study Outline
Many questions are written to assess your clinical application of the material
... [Show More] from the textbook, in real-world scenarios.
Chapter 25: Drugs Used in Treating Inflammatory Processes (p. 801-834 only)
• Know the pharmacodynamics, pharmacotherapeutics clinical use, drug interactions and adverse drug reactions for:
• Non-steroidal anti-inflammatory drugs (NSAIDs)
o pharmacotherapeutics clinical use
▪ NSAIDS inhibit cyclo-oxygenase (COX-1 and COX-2) activity, thus inhibiting prostaglandin synthesis.
▪ COX-1 is present in all tissues and cells, especially platelets; endothelial cells; the GI tract; and renal microvasculature, glomeruli, and collecting ducts.
▪ COX-2 is an "inducible" enzyme that is synthesized mainly in response to pain and inflammation.
▪ NSAIDs are primarily used for their anti-inflammatory activity but are also effective analgesics for the relief of mild to moderate pain
▪ Absorption
• Rapidly absorbed after oral administration
• Food delays absorption.
▪ Metabolism
• NSAIDs are metabolized by liver and excreted in urine.
• Acetaminophen is metabolized by liver.
• When acetaminophen is taken regularly or in large doses, the stores of glutathione become depleted and hepatic necrosis may occur.
▪ Clinical use:
• Rheumatoid arthritis
o Use NSAID or celecoxib to reduce joint pain and swelling.
o Follow American College of Rheumatology suggestions for treatment.
o Increased risk for complications, so monitor closely
• Osteoarthritis
o Acetaminophen or NSAIDs can be used for pain.
• Gout
o Indomethacin, naproxen, and sulindac
• Mild to moderate pain
o Nonopioid analgesia includes NSAIDs and acetaminophen.
o Ibuprofen and naproxen most commonly used
• Primary dysmenorrhea
o NSAIDs (ibuprofen or naproxen) are drugs of choice.
• Tendonitis and bursitis
o Indomethacin SR, naproxen, and sulindac
• Fever
o Ibuprofen is drug of choice.
• Drug of choice for mild to moderate pain in
o Pregnancy
o Patients with history of GI bleed
o Aspirin allergy, blood coagulation disorders, upper GI disease
• Drug of choice for fever
o Above adults
o Children
o Especially children with fever during flu-like illness [Show Less]