Generic Name: aspirin Brand Name: Easprin, Ecotrin Dose: Pain and Fever
Adults:
325-650 mg orally/rectally once every 4-6 hours as
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Controlled/extended/delayed- release products (enteric-coated): 650-1300 mg orally once every 8 hours; not to exceed 3.9 g/day
Children under 12 years:
10-15 mg/kg orally once every 4 hours, up to 60-80 mg/kg/day
Children 12 years and older: 325-650 mg orally/rectally once every 4-6 hours as needed
Controlled/extended/delayed- release products (enteric coated): 650-1300 mg orally once every 8 hours; not to exceed 3.9 g/day Drug Classification:
- Analgesic, Anti-inflammatory, Antiplatelet, Antipyretic, Antirheumatic, NSAID, Salicylate.
Therapeutic Action:
- Analgesic and antirheumatic- inhibits prostaglandin (an inflammatory mediator) synthesis Antipyretic effect – this action is not fully understood but drug study of aspirin is correlated with the ability of the drug to act in the thermoregulatory center of the hypothalamus by blocking the endogenous pyrogen through inhibiting synthesis of prostaglandin intermediary. Antiplatelet – aspirin drug study reveals the ability of the drug to inhibit thromboxame A2 (a potent vasoconstrictor and inducer of platelet aggregation) synthesis. Side Effects:
• Abdominal or stomach pain, cramping, or burning
• black, tarry stools
• bloody or cloudy urine
• change in consciousness
• chest pain or discomfort
• confusion
• constipation
• convulsions, severe or continuing
• dark urine
• decreased frequency or amount of urine
• diarrhea
• difficult breathing
• drowsiness
• fainting
• fast breathing
• feeling that something terrible will happen
• fever
• general tiredness and weakness
• greatly decreased frequency of urination or amount of urine
• headache
• heartburn
• increased thirst (Observe the 10 Rs of Medication Administration)
• Instruct patient to take salicylates with a full glass of water and to remain in an upright position for 15– 30 min after administration.
• Advise patient to report tinnitus; unusual bleeding of
gums; bruising; black, tarry stools; or fever lasting longer than 3 days.
• Check and verify with doctor’s order and Kardex.
• Observe rights in medication administration such as giving the right drug to the right patient using the right route and at the right time.
• Assess skin color and presence of lesions as this may indicate hepatotoxicity, allergy, bleeding, and other complications.
• Assess patient’s orientation to time and place as the drug may cause dizziness and
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