The four phases of the cell cycle, in order, are G1, __________________, __________________, and __________________. A cell contains the most DNA after
... [Show More] __________________ phase of the cell cycle. A cell is smallest in size after __________________ phase of the cell cycle. Growth occurs in __________________, __________________, and __________________ phases of the cell cycle. A cell does not enter mitosis until it has completed __________________ synthesis.What would be the most obvious outcome of repeated cell cycles consisting of S phase and M phase only?A mutant yeast strain stops proliferating when shifted from 25°C to 37°C. When these cells are analyzed at the two different temperatures, using a machine that sorts cells according to the amount of DNA they contain, the graphs in Figure Q183 are obtained.Which of the following would not explain the results with the mutant?Which of the following events does not usually occur during interphase?In which phase of the cell cycle do cells check to determine whether the DNA is fully and correctly replicated?What would happen to the progeny of a cell that proceeded to mitosis and cell division after entering S phase but had not completed S phase? Keep in mind that highly condensed chromatin, including the centromere region, is replicated late in S phase. Explain your answer.Are the statements below true or false? Explain your answerWhich of the following statements about the cell cycle is false?Which of the following descriptions is consistent with the behavior of a cell that lacks a protein required for a checkpoint mechanism that operates in G2?Match the following labels to the numbered label lines on Figure Q1810.Progression through the cell cycle requires a cyclin to bind to a Cdk because _________.2Levels of Cdk activity change during the cell cycle, in part because ________________.The concentration of mitotic cyclin (M cyclin) ________________.You have isolated a strain of mutant yeast cells that divides normally at 30°C but cannot enter M phase at 37°C. You have isolated its mitotic cyclin and mitotic Cdk and find that both proteins are produced and can form a normal MCdk complex at both temperatures. Which of the following temperaturesensitive mutations could not be responsible for the behavior of this strain of yeast?You engineer yeast cells that express the M cyclin during S phase by replacing the promoter sequence of the M cyclin gene with that of S cyclin. Keeping in mind that yeast cells have one common Cdk that binds to all cyclins, which of the following outcomes is least likely during this experiment?6You have isolated a mutant in which a fraction of the new cells die soon after cell division and a fraction of the living cells have an extra copy of one or more chromosomes. When you grow the cells under conditions in which they transit the cell cycle more slowly, the defect disappears, suggesting that the mitotic spindle and segregation machinery are normal. Propose a basis for the defect.Which of the following statements is false?For each of the following sentences, fill in the blanks with the best word or phrase selected from the list below. Not all words or phrases will be used; each word or phrase should be used only once.Many features of __________________ cells make them suitable for biochemical studies of the cellcycle control system. For example, the cells are unusually large and are arrested in a __________________like phase. When the cells are triggered to resume cycling, the cell divisions have especially __________________ G1 and G2 phases and occur __________________. Studies with Xenopus eggs identified a partly purified activity called __________________ that drives a resting Xenopus oocyte into M phase. MPF activity was found to __________________ during the cell cycle, although the amount of its kinase component, called __________________, remained constant. The regulatory component of MPF, called __________________, has a __________________ effect on MPF activity and plays a part in regulating interactions with its __________________s. The components of MPF are evolutionarily __________________ from yeast to humans, so that the corresponding human genes are __________________ to function in yeastMPF activity was discovered when cytoplasm from a Xenopus Mphase cell was injected into Xenopus oocytes, inducing the oocytes to form a mitotic spindle. In a control experiment, Xenopus interphase cytoplasm was injected into oocytes and shown not to induce the formation of a mitotic spindle. Which of the following statements is not a legitimate conclusion from the control experiment?Which of the following is not good direct evidence that the cellcycle control system is conserved through billions of years of divergent evolution?1Your friend is intrigued by Cdks and purifies Cdk from the daisy plant. She is able to determine the sequence of 18 amino acids from the daisy protein. Using these data, she aligns the daisy sequence with one human Cdk protein and the Cdk proteins from two different kinds of yeast, as shown in Figure Q1821. Sequences identical between the human and fungal proteins have been boxed.Mitogens are _____.The Retinoblastoma (Rb) protein blocks cells from entering the cell cycle by ______.Irradiated mammalian cells usually stop dividing and arrest at a G1 checkpoint. Place the following events in the order in which they occur.The G1 DNA damage checkpoint ________________.Cells in the G0 state ________________.What is the main molecular difference between cells in a G0 state and cells that have simply paused in G1?How does S–Cdk help guarantee that replication occurs only once during each cell cycle?You create cells with a version of Cdc6 that cannot be phosphorylated and thus cannot be degraded. Which of the following statements describes the likely consequence of this change in Cdc6? [Show Less]