CPHON Test 46 Questions with Verified Answers
Which virus is the only FDA approved vector for oncolysis? - CORRECT ANSWER Herpesvirus
Beta
... [Show More] thalassemia is caused by genetic abnormality on chromosome? - CORRECT ANSWER 11
most spinal cord mets are from which cancer? - CORRECT ANSWER sarcomas
what is the most common compliant from spinal cord mets? - CORRECT ANSWER back pain
what is the treatment for spinal cord mets? - CORRECT ANSWER steroids to reduce edema and radiation to reduce tumor size
favorable prognosis for ALL?
_____ +
____PLOIDY
TRANSLOCATION T(__:___) (P___:____) - CORRECT ANSWER calla, hyper,12,21,21,22
IT ________ always given with diagnostic LP for leukemia - CORRECT ANSWER cytarabine
Chromosomal breakage syndromes that increase the risk for leukemia?
"hint: getting leukemia is not FABulous" - CORRECT ANSWER falconi anemia, Bloom syndrome, ataxia-telangiectasia
if you are between the ages of ___ and ___, you are standard risk for leukemia - CORRECT ANSWER 2, 10
The peak age for B cell ALL is ____ - CORRECT ANSWER 2-5, preschoolers
T cell leukemia is associated with ________ mass and ______ WBC. Most common in adolescent ________. - CORRECT ANSWER mediastinal, elevated, males
Philadelphia chromosome is unfavorable for ALL.
____________ gene - CORRECT ANSWER BCR/ABL
there is a 75-80% survival rate for ________ patients - CORRECT ANSWER leukemia
peak age group to get AML is ______ and _______.
think of ILP/DS - CORRECT ANSWER neonates, teens
________ patients have a higher risk of DIC (leukemia) - CORRECT ANSWER AML
AML treatment includes cytarabine which puts these patients at a high risk for _________ sepsis. Vanco given with all fevers - CORRECT ANSWER alpha strep
the treatment for CML patients is _________ for life
ex: imatnib, dasatinib
only proven cure for these patients is a ______. - CORRECT ANSWER tyrosine kinase inhibitors
transplant
______
ATRA + arsenic trioxide is the treatment - CORRECT ANSWER APL
APL has a high risk of ________ with intiation of chemotherapy. monitor D-DIMER.
APL differentiation syndrome can occur. (sepsis/CLS = like picture).
Treatment: __________ - CORRECT ANSWER DIC, dexamethasone
thalassemia is an autosomal ________ disease - CORRECT ANSWER recessive
________ is a mutation on the globin gene needed for the synthesis of hgb - CORRECT ANSWER thalassemia
Hemophilia is _________ disorder - CORRECT ANSWER x linked
Gadolinium is most often used with which of the following imaging types?
Magnetic resonance imaging
Computed tomography scan
Bone scan
Positron emission tomography - CORRECT ANSWER A: Gadolinium is a rare earth element (Gd) with atomic number 64. Because of its paramagnetic properties, solutions of organic Gd compounds are often used as contrast agents in magnetic resonance imaging, especially if a brain or spinal cord tumor is suspected. Computed tomography scans also use different contrast agents that may be given orally, intravenously, or even rectally, depending on the area being studied. The image planes are then assembled and organized by the computer. Bone scanning uses a radioactive, bone-seeking compound that may disclose areas of osteolytic or osteoblastic activity consistent with a malignant tumor. Positron emission tomography employs isotopic 18-fluorodeoxyglucose, which can produce images of metabolic activity. It is quite valuable in determining the sites of tissue necrosis and metastatic disease in lymphomas, bone tumors, and neuroblastoma among many others.
Which of the following may be sites of extramedullary (nonhematolgic) leukemic infiltration?
Central nervous system
Spleen
Lymph nodes
All of the above - CORRECT ANSWER D: Leukemic infiltrates may occur in many organs and occasionally are the presenting clinical finding. Common sites are the liver, spleen, lymph nodes, and thymus. Testicular involvement is not unusual in acute lymphoblastic leukemia. Acute myelocytic leukemia may infiltrate the skin, oral cavity, head and neck area, or form myeloblastomas (chloromas) that resemble solid tumors and may be found in skin, soft tissue, bone, or other organs. Sometimes leukemia is asymptomatic and discovered on a routine blood count. The presence of leukemic cells or more than five white blood cells in the cerebrospinal fluid suggests central nervous system or meningeal involvement as does a cranial nerve palsy. This may result in a relapse from this location, and intrathecal chemotherapy is required.
Biologic response modifiers (BRMs) in cancer patients are used to enhance the body's immune system or other pathways to eliminate malignant cells. All of the following are BRMs EXCEPT:
cytokines
monoclonal antibodies
tacrolimus
tyrosine kinase inhibitors - CORRECT ANSWER Tacrolimus is an immunosuppressant that inhibits T-cell activation and has been used for the prevention or treatment of graft-versus-host disease. Biological response modifiers are agents that modify the immune system to enhance the elimination of tumor cells. These may include: monoclonal antibodies, such as infliximab, which has been used for B-cell lymphomas and acute lymphoblastic leukemia; cytokines, such as interferon, which have a direct antiproliferative effect; interleukins, which may modify immune-cell signaling; and tyrosine kinase inhibitors, such as imatinib, which block cellular phosphorylation and inhibit cellular transduction pathways in tumor cells. Vaccines are also in this category although they have thus far been used mostly for cancer prevention (e.g., human papillomavirus quadrivalent for the prevention of cervical cancer), but several are under development for therapy.
A vesicant chemo agent - CORRECT ANSWER Mitromycin
Max days Tordol for sickle cell - CORRECT ANSWER 5
Antiphospholipid syndrome - CORRECT ANSWER Hypercoagability
Teenager with anorexia AML - CORRECT ANSWER Promote comfortable eating environment
Patient with Factor VIII deficiency and ankle pain do what 1st - CORRECT ANSWER Give factor replacement not X-ray pain 1st sign bleeding
Hypogondism is Related to which chemo med - CORRECT ANSWER Busulfan
Used to tx pneumonia caused by cytomegalovirus - CORRECT ANSWER Grancidovir
Evidence based practice - CORRECT ANSWER Ask appraise apply asses
Cancer highly resistant to radiation - CORRECT ANSWER Osteosarcoma
Unfavorable in ALL - CORRECT ANSWER Hypodiploidy
Side effect of tactolimus - CORRECT ANSWER Low mag
Chemo associated with neurogenic sequelse - CORRECT ANSWER Cytarabine
Gives myelodysplasia - CORRECT ANSWER Ifosfomide
Brain tumor highest risk of increased icp - CORRECT ANSWER Medulloblastoma
Oncogenes causes - CORRECT ANSWER Uncontrolled cell growth
Ethical duty to tell the truth - CORRECT ANSWER Veracity
Dendritic cells found in - CORRECT ANSWER Langerhans cell histocytosis
Hgb Bart's related to - CORRECT ANSWER Thalassemia ask about miscarriage
Put less than 10 kg chemo bases on - CORRECT ANSWER Weight not BSA
sickle cell anemia at risk for - CORRECT ANSWER Retinopathy eye checks at school age
Tool to check sleep disturbance school age - CORRECT ANSWER BEAR [Show Less]