• Question 1
2 out of 2 points
Cell cycle-specific anticancer drugs require less frequent dosing/administration in order to prevent tumor
... [Show More] resistance.
Selected Answer: False
Correct Answer:
Fals e
• Question 2
2 out of 2 points
Anticancer drugs are highly distributed into cancer cells because of the increased capacity of these cancer cells for angiogenesis.
Selected Answer: False
Correct Answer:
Fals e
• Question 3
0 out of 2 points
Hematolymphoid cells express large numbers of MDR1 and ABCG2 making them highly sensitive to chemotherapeutic drugs.
Selected Answer: True
Correct Answer:
Fals e
• Question 4
2 out of 2 points
Increased tumor heterogenicty increases the likelihood for chemoresistance in tumors.
Selected Answer: True
Correct Answer:
Tru e
• Question 5
2 out of 2 points
A possible mechanism of tumor resistance to Methotrexate is the increased expression of reduced folate carriers by the tumor cells.
Selected Answer: False
Correct Answer:
Fals e
• Question 6
2 out of 2 points
Folate deficiency in a cancer patient being treated with 5-Fluorouracil will lead to diminished capacity of this drug to inhibit thymidylatesynthase.
Selected Answer: True
Correct Answer:
Tru e
• Question 7
0 out of 2 points
Increased expression of the p53 gene in a cancer patient will result in increased rate of apoptosis following chemotheray.
Selected Answer: True
Correct Answer:
Fals e
• Question 8
You are evaluating a 55 year old breast cancer patient who has been
2 out of 2 points
on Raloxifene and Pertuzumab for the past year, which of these features do you think is least indicative of tumor resistance?
Selected
Answer: Tumor regression and remission after
therapy
Correct
Answer: Tumor regression and remission after
therapy
• Question 9
2 out of 2 points
In which of these malignancies do you think that chemotherapy has been the least successful in producing tumor remission?
Selected Answer: Beast
Cancer
Correct Answer: Beast
Cancer
• Question 10
Which of these physiologic mechanisms of drug resistance is overcome by the intrathecal administration of chemotherapeutic agents in leukemia?
Selected
Answer: Drug Sanctuary
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