Hegar's sign
Softening of lower uterine segment
Chadwick's sign
Bluish color of cervix and vagina at 6-8 weeks
Goodell's sign
Softening
... [Show More] of cervix at 4+ weeks
Lipids in chronic inactivity
Low HDL
Lipids in under- or untreated hypothyroidism
Elevated total cholesterol, TG, and LDL
Lipids in chronic renal insufficiency
Elevated total cholesterol and TG
Lipids in alcohol abuse
Elevated TG, HDL, and LDL
Vaccines with live attenuated viruses
MMR, varicella, flu-mist(intranasal), Zostavax
Drugs of choice for abdominal infection
Beta lactams + metronidazole (most common); fluoroquinolones
Drugs of choice for urinary tract infection
Fluoroquinolones (except moxi), TMP-SMX, fluconazole, b-lactams, nitrofurantoin, fosfomycin if pt has many allergies
Drugs of choice for pulmonary infections
Macrolides, resp fluoroquinolones, b-lactams, doxycycline (MRSA, atypical coverage)
Drugs of choice for skin and soft tissue infections
MRSA: TMP-SMZ, doxycycline, clindamycin; b-lactams
Drugs of choice for MRSA
Vancomycin, daptomycin , linezolid, TMP-SMZ, doxycycline, ceftaroline
Macrolide drugs
Erythromycin, clarithromycin, azithromycin
Macrolide AEs
GI, QT prolongation
Tetracycline uses
MRSA, rocky mtn spotted fever, atypicals (mycoplasma pneumonia, chlamydia), spirochetes (Lyme), h.pylori
Tetracycline AEs
GI, teeth, hepatic dysfunction, photosensitivity
Fluoroquinolone drugs
Ciprofloxacin, levofloxacin, moxifloxacin
Fluoroquinolone uses
UTI (cipro or levo), atypicals (mycoplasma, legionella)
Fluoroquinolones and dairy or vitamins
Take 2 hrs before or 4 hours after (decrease concentrations)
Metronidazole (Flagyl) uses
C. Diff, vaginitis
Metronidazole AEs
GI, peripheral neuropathy, disulfiram reaction
Nitrofurantoin uses
UTI -not pyelonephritis due to no systemic absorption
Nitrofurantoin AEs, contraindications
Pulmonary fibrosis, contraindicated in CrCl <60 (excludes many elderly)
Aminoglycoside drugs
Gentamycin, tobramycin
Aminoglycoside uses
Atypical coverage, resistant infections, tobramycin for CF only
Aminoglycoside AEs
Ototoxicity (irreversible), nephrotoxicity (reversible)
Aminoglycoside monitoring
Renal dose adjust, hearing test, drug level monitoring
Antifungals (azoles)
Fluconazole, itraconazole
Itraconazole interactions
Acid suppressive therapies
Fluconazole dose adjust
Renal
Antifungal AEs
GI, QTc prolongation (fluconazole)
Antifungal drug interactions
QT prolongation meds, warfarin
Anti-infectives not for pregnant
Tetracyclines, TMP-SMZ
TMP-SMZ coverage
G+, G-, MRSA, Protozoa (toxoplasma gondii), fungus (pneumocystis jirovecii), poor anaerobic activity
TMP-SMZ AEs
Sulfa allergy, photosensitivity, hematologic (anemia, leukopenia, thrombocytopenia)
TMP-SMZ on renal function
Dose adjust in renal impairment, false elevation in serum Cr
TMP-SMZ drug interactions
Warfarin
Gram + only coverage
Clindamycin, linezolid, vancomycin, daptomycin
Gram - only
Monobactams (aztreonam), penicillin VK [Show Less]