The single best defining description of the classical pathway of complement activation is:
A It acts as a cascade
B It produces a C5 convertase
C In
... [Show More] generates the membrane attack complex (MAC)
D It results in the splitting of C3 into C3a and C3b
E It utilizes complement component C1r
2. The single best defining feature of a lymphocyte is that it is:
A A type of leukocyte
B A cell that is specialized to produce cytokines
C Present in the circulation
D Antigen-specific
E Able to undergo cell proliferation
3. The characteristic that best defines the acquired immune response IMMUNOLOGY[dse1]
From Medical Microbiology & Immunology
Examination & Board Review, 6th ed., 2000
W. Levinson & E. Jawetz
Directions (Questions 387-474): Select the ONE lettered answer that is BEST in each question.
387. Which category of hypersensitivity BEST describes hemolytic disease of the newborn
caused by Rh incompatibility?
A. atopic or anaphylactic
B. cytotoxic
C. immune complex
D. delayed
388. The principal difference between cytotoxic (type II) and immune complex (type III)
hypersensitivity is
A. the class (isotype) of antibody.
B. the site where antigen-antibody complexes are formed.
C. the participation of complement.
D. the participation of T cells.
389. A child stung by a bee experiences respiratory distress within minutes and lapses into
unconsciousness. This reaction is probably mediated by
A. IgE antibody.
B. IgG antibody.
C. sensitized T cells.
D. complement.
E. IgM antibody.
390. A patient with rheumatic fever develops a sore throat from which beta-hemolytic
streptococci are cultured. The patient is started on treatment with penicillin, and the sore throat
resolves within several days. However, 7 days after initiation of penicillin therapy the patient
develops a fever of 103°F, a generalized rash, and proteinuria. This MOST probably resulted
from
A. recurrence of the rheumatic fever.
B. a different infectious disease.
C. an IgE response to penicillin.
D. an IgG-IgM response to penicillin.
E. a delayed hypersensitivity reaction to penicillin.
391. A kidney biopsy specimen taken from a patient with acute glomerulonephritis and stained
with fluorescein-conjugated anti-human IgG antibody would probably show
A. no fluorescence.
B. uniform fluorescence of the glomerular basement membrane.
C. patchy, irregular fluorescence of the glomerular basement membrane.
D. fluorescent B cells.
E. fluorescent macrophages.
392. A patient with severe asthma gets no relief from antihistamines. The symptoms are MOST
likely to be caused by
A. interleukin-2.
B. slow-reacting substance A (leukotrienes).
C. serotonin.
D. bradykinin.
393. Hypersensitivity to penicillin and hypersensitivity to poison oak are both
A. mediated by IgE antibody.
B. mediated by IgG and IgM antibody.
C. initiated by haptens.
D. initiated by Th-2 cells.
394. A recipient of a 2-haplotype MHC-matched kidney from a relative still needs
immunosuppression to prevent graft rejection because
A. graft-versus-host disease is a problem.
B. minor histocompatibility antigens will not be matched.
C. minor histocompatibility antigens will not be matched.
D. [Show Less]