1) A disease that is present in unusually high numbers throughout the world is called a(n)
A) endemic.
B) epidemic.
C) sporadic.
D) pandemic.
2) A
... [Show More] ________ is a disease that primarily infects animals but can be transmitted to humans.
A) nosocomial infection
B) zoonosis
C) vector infection
D) mudurane
3) An inanimate object that transmits infectious agents between hosts is most appropriately called a
A) fomite.
B) carrier.
C) vector.
D) reservoir.
4) Which of the following is NOT a public health measure used to control the transmission of disease?
A) sanitary water and waste disposal methods
B) immunization
C) forced quarantine
D) genetic engineering
5) Which of the following is/are considered (a) direct contact infection(s)?
A) syphilis
B) gonorrhea
C) skin infections
D) syphilis, gonorrhea, and skin infections
6) The onset of a given epidemic is indicated by a sharp rise in the number of cases reported daily over a brief interval. This indicates that the mode of transmission is
A) host to host.
B) a common source.
C) insect vector.
D) mechanical vector.
7) Which of the following diseases is NOT normally spread by a common source?
A) measles
B) foodborne diseases
C) waterborne diseases
D) cholera
8) Which of the following is an example of herd immunity?
A) Brucellosis is no longer found in farm animals in the United States.
B) If 70% of the population is immunized against polio, the disease will be essentially absent from the population.
C) Federal law requires that all cattle not immune to anthrax be destroyed.
D) All farm animals used for food must be immunized against all the common agents of disease that infect humans.
9) Potential candidates for biological warfare
A) are generally gram-negative rather than gram-positive.
B) can be virtually any pathogenic bacterium or virus.
C) are eukaryotic rather than prokaryotic.
D) must be genetically engineered to be effective.
10) The incidence of HIV/AIDS among transfusion recipients has
A) increased since the discovery of HIV.
B) decreased since the discovery of HIV.
C) remained the same since the discovery of HIV.
D) never been more than a few individuals per year.
11) Which of the following shows the correct relationship among the epidemiology terms listed?
A) prevalence > incidence > mortality
B) incidence > prevalence > mortality
C) mortality > morbidity > prevalence
D) mortality > incidence > prevalence
12) Which of the following emergence factors has contributed to the HIV/AIDS epidemic?
A) climate change
B) rapid pathogen adaptation and change
C) increasing travel to endemic areas
D) exotic pet and meat trade
13) Treponema pallidum is extremely sensitive to temperature changes and low moisture, thus it is transmitted
A) by intimate person-to-person contact.
B) by fomites.
C) by vectors.
D) through common sources such as food and water.
14) The MOST common vectorborne disease in the United States is
A) influenza A.
B) Lyme disease.
C) malaria.
D) pneumonia.
15) A large number of cases of a particular disease observed in a relatively short period of time in an area that previously experienced only sporadic cases of the disease is known as a(n)
A) pandemic.
B) outbreak.
C) endemic.
D) zoonosis.
16) Which stage of an acute infectious disease occurs between the time the organism begins to grow in the host and the appearance of disease symptoms?
A) acute period
B) decline period
C) infection
D) incubation period
17) A marked seasonality to a disease is often indicative of
A) certain modes of transmission.
B) the presence of carriers.
C) a zoonotic infection.
D) a bacterial disease.
18) Which of the following are NOT vectors important in disease transmission?
A) fomites
B) insects
C) ticks
D) rodents
19) An example of a cyclical disease is
A) diphtheria.
B) smallpox.
C) influenza.
D) anthrax.
20) Which body site is preferentially infected by foodborne pathogens?
A) gastrointestinal tract
B) respiratory tract
C) cerebrospinal fluid
D) liver
21) Influenza pandemics occur cyclically because
A) less than 100% of the population is immunized.
B) new strains emerge due to reassortment between bird, swine, and human variants.
C) the vector is seasonal.
D) there are environmental reservoirs that release the virus during particular seasons.
22) Cholera is an example of a pandemic disease that
A) has multiple wild animal reservoirs and is thus difficult to eradicate.
B) spreads from a common source and could be controlled with adequate clean water and waste sanitation measures.
C) is spread through direct contact and has only a human reservoir.
D) has recently emerged due to overcrowding in urban centers.
23) Middle eastern respiratory syndrome (MERS) is caused by
A) Streptococcus pneumoniae.
B) the influenza virus.
C) a coronavirus.
D) a rhinovirus.
24) What is a/are potential reservoir(s) for viruses?
A) water
B) insects
C) bats
D) fomites
25) Which disease listed does NOT require quarantine?
A) smallpox
B) HIV/AIDS
C) plague
D) cholera
26) Filoviruses (such as Ebola virus) that cause severe hemorrhagic fevers generally have high ________ but low ________.
A) incidence / prevalence
B) prevalence / mortality
C) mortality / morbidity
D) morbidity / mortality
27) Which group of organisms is difficult to control through immunization because of their rapid and unpredictable genetic mutations?
A) vector-borne organisms
B) RNA viruses
C) Archaea
D) DNA viruses
28) Which public health measure(s) is/are MOST effective against pathogens transmitted through common vehicles?
A) water purification
B) mosquito control
C) food safety regulations
D) water purification and food safety regulations
29) Which of the following diseases would be the easiest to control in a human population?
A) an infectious disease with wild animals as a reservoir
B) an infectious disease with humans as the only reservoir
C) an infectious disease with domestic cows as the only reservoir
D) an infectious disease with several possible reservoirs
30) The number of ill individuals within a population is referred to as
A) morbidity.
B) mortality.
C) residency.
D) prevalence.
31) Disease ________ is measured by the total number of new reported disease cases within a population over a period of time.
A) incidence
B) frequency
C) morbidity
D) prevalence
32) Why did the H1N1 strain of influenza virus cause a pandemic in 2009?
A) The H1N1 virus had a mutation that increased the mortality associated with infection.
B) The H1N1 virus had a mutation that increased the basic reproduction number of the virus.
C) The H1N1 virus underwent a significant antigenic shift compared to other circulating strains of influenza.
D) The H1N1 virus acquired a new gene from pigs that resulted in increased virulence.
33) A nonliving source of an infectious agent that infects a large number of people is called a
A) fomite.
B) reservoir.
C) vector.
D) vehicle.
34) The study of the occurrence, distribution, and determinants of health and disease in a population is the field of
A) microbiology.
B) immunology.
C) epidemiology.
D) virology.
35) People who have a subclinical case of a disease are frequently ________ of a particular disease.
A) fomites
B) carriers
C) vectors
D) vehicles
36) With regards to mode of disease transmission, respiratory pathogens are generally ________, and intestinal pathogens are generally spread by contaminated ________.
A) spread by direct contact / vectors
B) spread by indirect contact / carriers
C) more transmissible / needles
D) airborne / food or water
37) A disease showing a relatively slow, progressive rise followed by a gradual decline in incidence is indicative of a(n)
A) host-to-host epidemic.
B) common source epidemic.
C) biological weapon.
D) endemic disease.
38) Diseases that are good candidates for eradication have
A) only a human reservoir.
B) no asymptomatic phase.
C) an environmental reservoir.
D) only a human reservoir and no asymptomatic phase.
39) Disease cases that exhibit new syndromes or characteristics or are linked to new pathogens are surveyed through regional laboratories and considered ________ cases.
A) zoonotic
B) index
C) endemic
D) epidemic
40) Diseases that suddenly become prevalent are referred to as ________ diseases.
A) indirect
B) emerging
C) vector
D) common source
41) Pasteurization of milk is an example of a disease control measure aimed at
A) preventing host-to-host transmission.
B) controlling the disease vector.
C) preventing common source diseases.
D) eliminating the disease reservoir.
42) "Typhoid Mary" is an example of a ________, because she was infected by the causative agent for typhoid fever yet was asymptomatic.
A) fomite
B) carrier
C) vector
D) vehicle
43) Most cases of mosquito-transmitted diseases occur in
A) the summer and fall seasons.
B) tropical and sub-tropical regions.
C) rural areas.
D) tropical and sub-tropical regions or during the summer and fall seasons.
44) Over time, the relationship between a pathogen and a naïve susceptible population tends towards
A) the extinction of the host.
B) the extinction of the pathogen.
C) a balance between host and pathogen such that both are maintained.
D) the extinction of either the host or the pathogen.
45) In 2003, the majority of AIDS deaths occurred in
A) South America.
B) North America.
C) Europe.
D) Sub-Saharan Africa.
46) Epidemiological studies of AIDS in Africa have confirmed that ________ transmission of the virus is the norm in that region.
A) fomite
B) indirect
C) heterosexual
D) homosexual
47) The basic reproduction number of a pathogen
A) can vary during an epidemic based on infection control measures.
B) can be determined experimentally in the lab.
C) is usually high for pathogens that are transmitted through direct contact.
D) can be determined experimentally and is usually high for pathogens that are transmitted through direct contact.
48) In just over a decade of efforts, the World Health Organization (WHO) eradicated smallpox by using worldwide
A) education campaigns.
B) destruction of infected domestic animals.
C) education campaigns and destruction of infected domestic animals.
D) vaccination programs.
49) Diseases can be controlled through immunization even if the percentage of the population that is immunized is less than 100% because
A) vectors can be controlled through other means.
B) most diseases lack reservoirs.
C) of herd immunity.
D) vehicles can be sterilized.
50) The term ________ is applied to strains and preparations of Bacillus anthracis that exhibit properties that enhance dissemination and use as biological weapons.
A) weaponized
B) virulized
C) category A
D) infectious
True/False Questions
1) A disease that is constantly present in low numbers is called an acute disease.
2) The incidence of HIV among hemophiliacs and transfusion recipients has remained constant since 1994.
3) Many pathogenic organisms require living hosts as reservoirs to survive.
4) Upper respiratory infectious agents are commonly transmitted from person to person.
5) Morbidity statistics more precisely define the health of a population than mortality statistics.
6) In the absence of susceptible hosts, Clostridium tetani would still survive in nature.
7) In the United States and other developed countries, deaths due to infectious diseases are decreasing.
8) An endemic disease is constantly present, usually at low incidence, in a population.
9) Reservoirs of infectious disease agents may be either animate or inanimate.
10) When the life cycle of a disease agent is dependent on a single host species, the pathogen can be eradicated.
11) Food and water are considered disease vehicles.
12) Failure to reach equilibrium with a disease agent could result in extinction for a host species.
13) Many parasites, such as those that cause malaria, use antigenic variation to decrease virulence within a specific host.
14) Immunization against endemic diseases is NOT necessary when traveling outside of one's home country or region.
15) Emerging infectious disease will likely affect only developing countries in the near future.
16) Changes in food processing and distribution can increase the incidence of new and emerging diseases.
17) To control a disease in a population, 100% immunization is necessary.
18) The lower the basic reproduction number of a pathogen, the higher the percentage of immune individuals necessary to provide herd immunity.
19) A disease that is transferred by direct intimate contact with a mortality rate over 90% would be an effective biological weapon.
20) A disease transferred by indirect contact with a high basic reproduction number and mortality would be an effective biological weapon.
Essay Questions
1) Give an example of an acute and a chronic carrier of disease. What disease characteristics allow for chronic carriers to play significant roles in the spread of the disease? How are diseases with chronic carriers controlled?
2) Why are diseases such as rabies that have a wild animal reservoir so difficult to eradicate while other diseases such as brucellosis that reside in domestic animals have been virtually eradicated.
3) What measures would be taken if a case of smallpox were recognized in a world traveler after the individual had debarked from Heathrow airport in England following several days of sightseeing in London?
4) What happened in Australia when rabbit hemorrhagic disease virus was released to control the rabbit population?
5) You are planning a whitewater rafting vacation in Kenya. Based on what you know about microbiology, what precautions should you take to return in the best of health?
6) How can epidemiologist differentiate between common-source and host-to-host epidemics based only on the incidence of disease?
7) Explain the concept of coevolution in terms of host-pathogen interactions.
8) List and discuss five factors responsible for the emergence of new pathogens or the reemergence of existing pathogens.
9) Rodents have been associated with numerous severe epidemics in the past, prompting microbiologist Hans Zinsser in the 1930s to write a book, Rats, Lice, and History, in which he documented the important role of rodents in epidemics. Discuss why rodent control is still desirable, even in an age when it is perceived that the "magic bullets" of chemotherapy and immunization to control infectious disease are readily available.
10) How might climate change impact the incidence of a disease? Use a specific example to illustrate your answer.
11) What are the five stages of a typical infectious disease? During which stage is the host likely to infect others?
12) Why are public health officials concerned about smallpox being used as a biological weapon? Give several reasons in your answer. [Show Less]